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Efficient and safe delivery of saRNA into target cells remains a critical hurdle, with lipid nanoparticles (LNPs) and other delivery systems currently being optimized to address this issue. Ensuring the long-term safety of saRNA is also important, and ongoing research is focused on minimizing potential side effects and immune reactions.
To identify an saRNA that can activate a gene of interest, several saRNAs need to be designed within a 1- to 2-kbp promoter region by following a set of rules [3] [4] and tested in cultured cells. In some reports, saRNAs are designed in such a way to target non-coding transcripts that overlap the promoter sequence of a protein coding gene.
The first saRNA Covid vaccine authorised was Gemcovac, in India in June 2022. [102] The second was ARCT-154, developed by Arcturus Therapeutics. A version manufactured by Meiji Seika Pharma was authorised in Japan in November 2023. [103] GSK began a phase 1 trial of an saRNA COVID-19 vaccine in 2021. [104]
Beneficial side effects are less common; some examples, in many cases of side-effects that ultimately gained regulatory approval as intended effects, are: Bevacizumab ( Avastin ), used to slow the growth of blood vessels, has been used against dry age-related macular degeneration , as well as macular edema from diseases such as diabetic ...
[51] [56] Most side effects are mild to moderate in severity and resolve within a few days. [2] [57] Common side effects include mild to moderate pain at the injection site, fatigue, and headaches. [58] [59] Reports of serious side effects, such as allergic reactions, remain very rare [a] with no long-term complications documented. [2] [61]
Common Side Effects is an American adult animated television series created by Joseph Bennett and Steve Hely for Cartoon Network's Adult Swim block.. The series was first premiered at Annecy International Animation Film Festival in June 2024, but was publicly announced at San Diego Comic-Con on July 26, 2024.