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Antigen and antibody interact through a high affinity binding much like lock and key. [10] A dynamic equilibrium exists for the binding. For example, the reaction is a reversible one, and can be expressed as: [11] [] + [] []
The induced fit model is a development of the lock-and-key model and assumes that an active site is flexible and changes shape until the substrate is completely bound. This model is similar to a person wearing a glove: the glove changes shape to fit the hand. The enzyme initially has a conformation that attracts its substrate.
Using the "lock and key model" of enzyme binding, a drug (key) must be of roughly the proper dimensions to fit the enzyme's binding site (lock). [28] Using the appropriately sized molecular scaffold, drugs must also interact with the enzyme non-covalently in order to maximize binding affinity binding constant and reduce the ability of the drug ...
By understanding the method in which substances move along neurons or microtubules it is possible to target specific pathways for disease. Currently, many drug companies are aiming to utilize the trajectory of intracellular transport mechanisms to deliver drugs to localized regions and target cells without harming healthy neighboring cells.
In molecular biology, complementarity describes a relationship between two structures each following the lock-and-key principle.
One can think of molecular docking as a problem of “lock-and-key”, in which one wants to find the correct relative orientation of the “key” which will open up the “lock” (where on the surface of the lock is the key hole, which direction to turn the key after it is inserted, etc.). Here, the protein can be thought of as the “lock ...
A key question is therefore whether and how enzymes can change their enzymatic activities alongside. It is generally accepted that many new enzyme activities have evolved through gene duplication and mutation of the duplicate copies although evolution can also happen without duplication.
The terms "tabular key" and "matrix key" are best limited to a tabular presentation format of multi-access keys. [3] The term "synoptic key" has an older definition, defining it as a key reflecting taxonomic classification and opposed to diagnostic keys arranged solely for the convenience of identification. [1]