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In earlier stages, serum calcium, phosphate levels are normal at the expense of high parathyroid hormone and fibroblast growth factor-23 levels. X-rays will also show bone features of renal osteodystrophy (subperiostic bone resorption, chondrocalcinosis at the knees and pubic symphysis , osteopenia and bone fractures) but may be difficult to ...
2% (people in hospital) [1] Hypophosphatemia is an electrolyte disorder in which there is a low level of phosphate in the blood. [1] Symptoms may include weakness, trouble breathing, and loss of appetite. [1] Complications may include seizures, coma, rhabdomyolysis, or softening of the bones.
Osteomalacia is a disease characterized by the softening of the bones caused by impaired bone metabolism primarily due to inadequate levels of available phosphate, calcium, and vitamin D, or because of resorption of calcium. The impairment of bone metabolism causes inadequate bone mineralization. Osteomalacia in children is known as rickets ...
Calcium pyrophosphate dihydrate (CPPD) crystal deposition disease, also known as pseudogout and pyrophosphate arthropathy, is a rheumatologic disease which is thought to be secondary to abnormal accumulation of calcium pyrophosphate dihydrate crystals within joint soft tissues. [ 1 ] The knee joint is most commonly affected. [ 2 ]
Frequency. 15% (50 year olds), 70% (over 80 year olds) [ 7 ] Osteoporosis is a systemic skeletal disorder characterized by low bone mass, micro-architectural deterioration of bone tissue leading to more porous bone, and consequent increase in fracture risk. It is the most common reason for a broken bone among the elderly. [ 3 ]
Rare (1 in 100,000); [3] more common in some populations [4] Hypophosphatasia (/ ˌhaɪpoʊˈfɒsfeɪtˌeɪʒə /; also called deficiency of alkaline phosphatase, phosphoethanolaminuria, [5] or Rathbun's syndrome; [1] sometimes abbreviated HPP[6]) is a rare, and sometimes fatal, inherited [7] metabolic bone disease. [8]
Organophosphate poisoning is poisoning due to organophosphates (OPs). [4] Organophosphates are used as insecticides, medications, and nerve agents. [4] Symptoms include increased saliva and tear production, diarrhea, vomiting, small pupils, sweating, muscle tremors, and confusion. [2] While onset of symptoms is often within minutes to hours ...
The pyrophosphate anion has the structure P 2 O 4− 7, and is an acid anhydride of phosphate. It is unstable in aqueous solution and hydrolyzes into inorganic phosphate: P 2 O 4− 7 + H 2 O → 2 HPO 2− 4. or in biologists' shorthand notation: PP i + H 2 O → 2 P i + 2 H +