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MammaPrint. MammaPrint is a prognostic and predictive diagnostic test for early stage breast cancer patients that assess the risk that a tumor will metastasize to other parts of the body. [1] It gives a binary result, high-risk or low-risk classification, and helps physicians determine whether or not a patient will benefit from chemotherapy.
HRDetect. HRDetect [1] (H omologous R ecombination D eficiency D etect) is a whole-genome sequencing (WGS)-based classifier designed to predict BRCA1 and BRCA2 deficiency based on six mutational signatures. Additionally, the classifier is able to identify similarities in mutational profiles of tumors to that of tumors with BRCA1 and BRCA2 ...
For example, the incidence of breast cancer in a woman in the United Kingdom at age 55 to 59 is estimated at 280 cases per 100.000 per year, [6] and the risk factor of having been exposed to high-dose ionizing radiation to the chest (for example, as treatments for other cancers) confers a relative risk of breast cancer between 2.1 and 4.0, [7 ...
The y-axis shows the observed risk amounts, where the x-axis shows the groups separating in risk as they age—corresponding with the predicted risk scores. In genetics, a polygenic score (PGS) is a number that summarizes the estimated effect of many genetic variants on an individual's phenotype. The PGS is also called the polygenic index (PGI ...
Gene expression profiling is a technique used in molecular biology to query the expression of thousands of genes simultaneously. In the context of cancer, gene expression profiling has been used to more accurately classify tumors. The information derived from gene expression profiling often helps in predicting the patient's clinical outcome.
The Nottingham prognostic index (NPI) is used to determine prognosis following surgery for breast cancer. [1][2] Its value is calculated using three pathological criteria: the size of the tumour; the number of involved lymph nodes; and the grade of the tumour. [1] It is calculated to select patients for adjuvant treatment.
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