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  2. Beta blocker - Wikipedia

    en.wikipedia.org/wiki/Beta_blocker

    Beta blockers counter this inappropriately high sympathetic activity, eventually leading to an improved ejection fraction, despite an initial reduction in ejection fraction. [citation needed] Trials have shown beta blockers reduce the absolute risk of death by 4.5% over a 13-month period.

  3. Heart failure with preserved ejection fraction - Wikipedia

    en.wikipedia.org/wiki/Heart_failure_with...

    Some evidence suggests that vasodilating beta blockers, such as nebivolol, can provide a benefit for patients with heart failure regardless of ejection fraction. [58] Additionally, because of the chronotropic perturbation and diminished LV filling seen in HFpEF the bradycardic effect of beta blockers may enable improved filling, reduce ...

  4. Heart failure - Wikipedia

    en.wikipedia.org/wiki/Heart_failure

    Ivabradine is recommended for people with symptomatic heart failure with reduced left ventricular ejection fraction who are receiving optimized guideline-directed therapy (as above) including the maximum tolerated dose of beta-blocker, have a normal heart rhythm and continue to have a resting heart rate above 70 beats per minute. [114]

  5. Management of heart failure - Wikipedia

    en.wikipedia.org/wiki/Management_of_heart_failure

    The RALES trial [29] showed that the addition of spironolactone can improve mortality, particularly in severe cardiomyopathy (ejection fraction less than 25%.) The related medication eplerenone was shown in the EPHESUS trial [ 30 ] to have a similar effect, and it is specifically labelled for use in decompensated heart failure complicating ...

  6. Bisoprolol - Wikipedia

    en.wikipedia.org/wiki/Bisoprolol

    Zebeta 5-mg oral tablet. Bisoprolol is used for prevention of cardiovascular events following a heart attack in patients with risk factors for disease progression, [16] in the management of congestive heart failure with reduced ejection fraction, [17] and as a second-line agent for hypertension.

  7. Ivabradine - Wikipedia

    en.wikipedia.org/wiki/Ivabradine

    Given the selective decrease in rate without loss of contractility, ivabradine may prove efficacious for treatment of congestive heart failure with reduced ejection fraction. Ivabradine binds to HCN4 receptors (potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4), utilizing Y506, F509 and I510 residues. [17]

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