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Diazepam is stored at room temperature (15–30 °C). The solution for parenteral injection is kept so that it is protected from light and kept from freezing. The oral forms are stored in air-tight containers and protected from light. [30] Diazepam can be absorbed into plastics, so liquid preparations are not kept in plastic bottles or syringes ...
Temperature monitoring needs to take place in both storage units and transport units. The refrigerator should maintain a temperature between 2° and 8 °C (36° and 46 °F). Freezers should maintain a temperature between -50° and -15 °C (-58° and +5 °F). [ 14 ]
The USP Controlled Room Temperature is a series of United States Pharmacopeia guidelines for the storage of pharmaceuticals; [1] the relevant omnibus standard is USP 797. [2] [3] Although 100% compliance remains challenging for any given facility, [4] the larger protocol may be regarded as constituting a form of clean room [5] which is included in a suite of best practices.
The vaccine vial monitor consists of a temperature sensitive square within a circle. If the monitor is exposed to heat it changes color with time and with increasing speed in hotter conditions. If the square becomes the same color as the circle or becomes darker than the circle, then the vaccine contained in the vial is damaged and the vial ...
Most are used to monitor temperature conditions, and some versions can also measure the relative humidity. Data loggers are often small enough to be placed inside an insulated shipping container or directly attached to a product inside a refrigerator truck or a refrigerated container. These monitor the temperature of the product being shipped.
Critical temperature indicators: These monitor a critical temperature threshold that, if exceeded, may cause irreversible damage to the product. [ 3 ] Digital temperature data loggers are available to indicate the full temperature history of a shipment to help identify the time period that out-of- tolerance temperatures were encountered.
An Australian study (2004) of overdose admissions between 1987 and 2002 found alprazolam, which happens to be the most prescribed benzodiazepine in Australia and the United States, to be more toxic than diazepam and the other three benzodiazepines which it was compared to (alprazolam, diazepam, oxazepam, chlordiazepoxide, and clonazepam).
Chlordiazepoxide, 5 mg capsules, are sometimes used as an alternative to diazepam for benzodiazepine withdrawal. Like diazepam, it has a long elimination half-life and long-acting active metabolites. [25] [69] Management of benzodiazepine dependence involves considering the person's age, comorbidity and the pharmacological pathways of ...