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Caspase-3 shares many of the typical characteristics common to all currently-known caspases. For example, its active site contains a cysteine residue (Cys-163) and histidine residue (His-121) that stabilize the peptide bond cleavage of a protein sequence to the carboxy-terminal side of an aspartic acid when it is part of a particular 4-amino acid sequence.
Simple explanation of the mechanisms of apoptosis triggered by internal signals (bcl-2), along the caspase-9, caspase-3 and caspase-7 pathway; and by external signals (FAS and TNF), along the caspase 8 pathway. Accessed 25 March 2007. Apoptosis & Caspase 7, PMAP-animation; Caspases at the U.S. National Library of Medicine Medical Subject ...
It has been shown that blocking the extracellular domain of LINGO-1 disrupts the interaction between receptor kinases and LINGO-1 which directly attenuates inhibition of neuronal survival. However among the four WNK family members, only WNK3 has been shown to regulate and increase cell survival in a caspase-3-dependent pathway. [15] [18]
Caspase-3, an executioner caspase in apoptosis, can cleave gasdermin E (GSDME) to produce a N-terminal fragment and a C-terminal fragment in a way similar to GSDMD cleavage. [3] When apoptotic cells are not scavenged by macrophages, GSDME expression is then upregulated by p53. GSDME is then activated by caspase-3 to form pores on the cell membrane.
Survivin's role in cancer development in the context of a signaling pathway is its ability to inhibit activation of downstream caspase-3 and -7 from apoptosis inducing stimuli. The overexpression of survivin in tumors may serve to increase the tumors resistance to apoptosis and, thus, contribute to cell immortality even in the presence of death ...
7186 22030 Ensembl ENSG00000127191 ENSMUSG00000026942 UniProt Q12933 P39429 RefSeq (mRNA) NM_021138 NM_009422 NM_001290413 RefSeq (protein) NP_066961 NP_001277342 NP_033448 Location (UCSC) Chr 9: 136.88 – 136.93 Mb Chr 2: 25.41 – 25.44 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse TNF receptor-associated factor 2 is a protein that in humans is encoded by the TRAF2 gene ...
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