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para-Methoxyamphetamine (PMA), also known as 4-methoxyamphetamine (4-MA), is a designer drug of the amphetamine class with serotonergic effects. [2] [3] [4] Unlike other similar drugs of this family, PMA does not produce stimulant, euphoriant, or entactogen effects, [5] and behaves more like an antidepressant in comparison, [6] though it does have some psychedelic properties.
para-Methoxymethamphetamine (PMMA), also known as 4-methoxy-N-methylamphetamine (4-MMA), is a serotonergic drug of the amphetamine family related to para-methoxyamphetamine (PMA). It is the 4- methoxy analogue of methamphetamine .
Some of amphetamine's substituted derivatives occur in nature, for example in the leaves of Ephedra and khat plants. [1] Amphetamine was first produced at the end of the 19th century. By the 1930s, amphetamine and some of its derivative compounds found use as decongestants in the symptomatic treatment of colds and also occasionally as ...
para-Methoxy ethyl amphetamine (PMEA), is a stimulant drug related to PMA. PMEA reputedly produces similar effects to PMA, but is considerably less potent [1] and seems to have slightly less tendency to produce severe hyperthermia, at least at low doses. At higher doses however the side effects and danger of death approach those of PMA itself ...
An assortment of several designer drugs. Designer drugs are structural or functional analogues of controlled substances that are designed to mimic the pharmacological effects of the parent drug while avoiding detection or classification as illegal.
4-Methylthioamphetamine (4-MTA), also known as para-methylthioamphetamine (MTA), is a designer drug of the substituted amphetamine class developed in the 1990s by a team led by David E. Nichols, an American pharmacologist and medical chemist, at Purdue University. It acts as a non-neurotoxic highly selective serotonin releasing agent (SSRA) in ...
The extent of cutting can vary significantly over time but for the last 15 years drugs such as heroin and cocaine have often sat at the 50% purity level. [citation needed] Heroin purity sitting at 50% does not mean 50% cutting agents; other adulterants could include other opiate by-products of making heroin from opium.
The authors speculated that this is because 5-HT release dampens DA release through some mechanism. For example, it was suggested that a possible cause for this could be activation of 5HT 2C receptors since this is known to inhibit DA release. In addition there are alternative explanations such as 5-HT release then going on to encourage GABA ...