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Azacitidine is a chemical analogue of the nucleoside cytidine, which is present in DNA and RNA.It is thought to have antineoplastic activity via two mechanisms – at low doses, by inhibiting of DNA methyltransferase, causing hypomethylation of DNA, [16] and at high doses, by its direct cytotoxicity to abnormal hematopoietic cells in the bone marrow through its incorporation into DNA and RNA ...
Azacitidine and decitabine are marketed as Vidaza and Dacogen respectively. Azacitidine is the first drug to be approved by FDA for treating MDS and has been given orphan drug status. [2] [3] Procaine is a DNA-demethylating agent with growth-inhibitory effects in human cancer cells. [4]
A variety of cytidine analogues are known, some with potentially useful pharmacology. For example, KP-1461 is an anti-HIV agent that works as a viral mutagen, [5] and zebularine exists in E. coli and is being examined for chemotherapy.
Humans still don’t need to hibernate, Weiss said, nor can we afford to due to our social and occupational obligations. “But we can make adjustments to perform in a better way, to rest in a ...
This is a partial list of herbs and herbal treatments with known or suspected adverse effects, either alone or in interaction with other herbs or drugs.Non-inclusion of an herb in this list does not imply that it is free of adverse effects.
Naturally occurring oxidative DNA damages arise at least 10,000 times per cell per day in humans and as much as 100,000 per cell per day in rats [9] as documented below. Oxidative DNA damage can produce more than 20 types of altered bases [ 10 ] [ 11 ] as well as single strand breaks.
Topotecan is a semi-synthetic derivative of camptothecin.Camptothecin is a natural product extracted from the bark of the tree Camptotheca acuminata.Topoisomerase-I is a nuclear enzyme that relieves torsional strain in DNA by opening single strand breaks. [20]
When a tiger dies, his eyesight descends and turns into a white stone. Human blood will turn into phosphorus or jade when it drops to the ground." Li only gives one prescription, "Renpo pacifies the Heart and tranquilizes the soul and boldness. It treats convulsions, fright, and manic-depressive psychosis. Grind Renpo with water and take it by ...
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