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Comparative Effect on Bone Density, Endometrium, and Lipids of Continuous Hormones as Replacement Therapy (CHART) [8] Danish Osteoporosis Prevention Study (DOPS) (open-label) Early versus Late Intervention Trial with Estradiol (ELITE) Estrogen in Prevention of Atherosclerosis Trial (EPAT) Estrogen Replacement and Atherosclerosis (ERA)
Complex or multicomponent interventions use multiple strategies, [5] and they often involve the participation of several types of care providers. [6] Non-pharmacological interventions can call on various fields of expertise, such as surgery, medical devices, rehabilitation, psychotherapy, and behavioral interventions. [6]
The authors of the study recommended that women with non-surgical menopause take the lowest feasible dose of hormones for the shortest time to minimize risk. [ 97 ] The data published by the WHI suggested supplemental estrogen increased risk of venous thromboembolism and breast cancer but was protective against osteoporosis and colorectal ...
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SERMs are used for various estrogen-related diseases, including treatment of ovulatory dysfunction in the management of infertility treatment, prevention of postmenopausal osteoporosis, treatment and risk reduction of breast cancer, [4] and treatment of dyspareunia due to menopause.
Another recent analysis of Dietary Modification intervention outcomes showed a 30% reduction in coronary heart disease (CHD) risk among women having normal blood pressure (n = 23,248) and partaking in a low-fat dietary pattern (122 versus 256 CHD events; HR, 0.70; 95% CI, 0.56 to 0.87 during the intervention period).