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The etymology behind the term "clue" cell derives from the original research article from Gardner and Dukes describing the characteristic cells. The name was chosen for its brevity in describing the sine qua non of bacterial vaginosis. [1] They are a medical sign of bacterial vaginosis, particularly that caused by Gardnerella vaginalis, [2] a ...
A vaginal wet mount with a clue cell, indicating bacterial vaginosis. Bacterial vaginosis generally produces a vaginal discharge that is thin and milky with a fishy odor. [1] Diagnosis is made using Amsel Criteria - three of the four following criteria must be met: >20% of the epithelial cells are clue cells (the single most reliable predictor) [4]
If present, clue cells can be visualized under a microscope. They are so-named because they give a clue to the reason behind the discharge. These are epithelial cells that are coated with bacteria. Differential diagnosis for bacterial vaginosis includes the following: [42] Normal vaginal discharge. Candidiasis (thrush, or a yeast infection).
It has a Gram-positive cell wall, [7] but, because the cell wall is so thin, it can appear either Gram-positive or Gram-negative under the microscope. It is associated microscopically with clue cells, which are epithelial cells covered in bacteria. [citation needed] G. vaginalis produces a pore-forming toxin, vaginolysin, which affects only ...
Microscopic picture of vaginal epithelial clue cells coated with Gardnerella vaginalis, magnified 400 times Scientific classification; Domain: Bacteria: Phylum: Actinomycetota: Class: Actinomycetia: Order: Bifidobacteriales: Family: Bifidobacteriaceae: Genus: Gardnerella Greenwood and Pickett 1980 [1] Species [2] Gardnerella greenwoodii Sousa ...
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Bacterial vaginosis (BV) is an infection caused by a change in the vaginal flora, which refers to the community of organisms that live in the vagina. [20] It is the most common cause of pathological vaginal discharge in women of childbearing age and accounts for 40–50% of cases. [ 21 ]
Normal vaginal flora (left) is predominantly rod-shaped Lactobacilli, whereas in bacterial vaginosis (right) there is an overgrowth of bacteria, which can be of various species. A healthy vaginal microbiome aids in the prevention of bacterial vaginosis, yeast infections and other possible problems by maintaining an acidic pH (< 4.5) that is ...