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  2. Bone marrow - Wikipedia

    en.wikipedia.org/wiki/Bone_marrow

    Bone marrow is a semi-solid tissue found within the spongy (also known as cancellous) portions of bones. [2] In birds and mammals, bone marrow is the primary site of new blood cell production (or haematopoiesis). [3] It is composed of hematopoietic cells, marrow adipose tissue, and supportive stromal cells.

  3. Plasmacytoma - Wikipedia

    en.wikipedia.org/wiki/Plasmacytoma

    The proposed criteria for SPB is the presence of a single bone lesion, normal bone marrow (less than 5% plasma cells), small or no paraprotein, no related organ involvement/damage and a normal skeletal survey (other than the single bone lesion). The criteria for extramedullary plasmacytoma are the same but the tumor is located in soft tissue.

  4. Fanconi anemia - Wikipedia

    en.wikipedia.org/wiki/Fanconi_anemia

    Fanconi anemia (FA) is a rare, autosomal recessive, genetic disease resulting in impaired response to DNA damage in the FA/BRCA pathway. Although it is a very rare disorder, study of this and other bone marrow failure syndromes has improved scientific understanding of the mechanisms of normal bone marrow function and development of cancer.

  5. Aplastic anemia - Wikipedia

    en.wikipedia.org/wiki/Aplastic_anemia

    Normal bone marrow has 30–70% blood stem cells, but in aplastic anemia, these cells are mostly gone and are replaced by fat. [ 5 ] [ 6 ] First-line treatment for aplastic anemia consists of immunosuppressive drugs —typically either anti-lymphocyte globulin or anti-thymocyte globulin —combined with corticosteroids , chemotherapy , and ...

  6. Megakaryocyte - Wikipedia

    en.wikipedia.org/wiki/Megakaryocyte

    A megakaryocyte (from mega- 'large' karyo- ' cell nucleus ' and -cyte ' cell ') is a large bone marrow cell with a lobated nucleus that produces blood platelets (thrombocytes), which are necessary for normal clotting. In humans, megakaryocytes usually account for 1 out of 10,000 bone marrow cells, but can increase in number nearly 10-fold ...

  7. Granulopoiesis - Wikipedia

    en.wikipedia.org/wiki/Granulopoiesis

    A granulocyte, also referred to as a polymorphonuclear leukocyte (PMN), is a type of white blood cell that has multi lobed nuclei, usually containing three lobes, and has a significant amount of cytoplasmic granules within the cell. [ 1 ] Granulopoiesis takes place in the bone marrow. [ 2 ] It leads to the production of three types of mature ...

  8. Canine histiocytic diseases - Wikipedia

    en.wikipedia.org/wiki/Canine_histiocytic_diseases

    Canine histiocytic diseases. Histiocytic diseases in dogs are a group of diseases in dogs which may involve the skin, and which can be difficult to differentiate from granulomatous, reactive inflammatory or lymphoproliferative diseases. The clinical presentation and behaviour as well as response to therapy vary greatly among the syndromes.

  9. Hemosiderin - Wikipedia

    en.wikipedia.org/wiki/Hemosiderin

    Hemosiderin or haemosiderin is an iron -storage complex that is composed of partially digested ferritin and lysosomes. The breakdown of heme gives rise to biliverdin and iron. [1][2] The body then traps the released iron and stores it as hemosiderin in tissues. [3] Hemosiderin is also generated from the abnormal metabolic pathway of ferritin.