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These three drugs work in combination to target the HIV reverse transcriptase protein in three ways, which reduces the virus's capacity to mutate. [ 5 ] In combination studies there were synergistic antiviral effects observed between emtricitabine and efavirenz, efavirenz and tenofovir, and emtricitabine and tenofovir.
If a pregnant woman presents in labor with an unknown HIV status and a positive rapid HIV test result or an infant has a high risk of HIV transmission in utero (for example, the mother was not taking antiretroviral drugs in the pre-pregnancy period or during pregnancy, the mother had not achieved viral suppression, or the mother experienced an ...
Injection of drugs in the last six months with sharing of equipment Serodiscordant heterosexual and homosexual partners, where one partner is HIV-positive and the other HIV-negative The consideration of utilizing emtricitabine/tenofovir as a reduction strategy involves discussion with a health professional who can help the patient navigate the ...
AZT was usually dosed twice a day in combination with other antiretroviral therapies. This approach is referred to as Highly Active Antiretroviral Therapy and is used to prevent the likelihood of HIV resistance. [11] [12] As of 2019, the standard is a three-drug once-daily oral treatment that can include AZT. [13]
Atazanavir, sold under the brand name Reyataz among others, is an antiretroviral medication used to treat HIV/AIDS. [2] It is generally recommended for use with other antiretrovirals. [2] It may be used for prevention after a needlestick injury or other potential exposure (postexposure prophylaxis (PEP)). [2] It is taken by mouth. [2]
Nevirapine in triple combination therapy has been shown to suppress viral load effectively when used as initial antiretroviral therapy (i.e., in antiretroviral-naive patients). [8] Some clinical trials have demonstrated comparable HIV suppression with nevirapine-based regimens to that achieved with regimens based on a protease inhibitor (PI ...
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