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This is why all modern GWAS use a very low p-value threshold. In addition to easily correctible problems such as these, some more subtle but important issues have surfaced. A high-profile GWA study that investigated individuals with very long life spans to identify SNPs associated with longevity is an example of this. [72]
[2] [3] [4] It is a complementary approach to the genome-wide association study, or GWAS, methodology. [5] A fundamental difference between GWAS and PheWAS designs is the direction of inference: in a PheWAS it is from exposure (the DNA variant) to many possible outcomes, that is, from SNPs to differences in phenotypes and disease risk.
In the field of genetic sequencing, genotyping by sequencing, also called GBS, is a method to discover single nucleotide polymorphisms (SNP) in order to perform genotyping studies, such as genome-wide association studies (). [1]
GWAS Central is a core component of the GEN2PHEN project and intends to provide an operational model, plus an open-source software package, so others can create similar databases across the world. These will be hosted by institutes, consortia, and even individual laboratories; providing those groups a toolkit for publicising and publishing ...
An important factor to consider when planning a genetic study is the frequency and risk incurred by specific alleles. These factors can vary in different populations so the HapMap project used a variety of sequencing techniques to discover and catalog SNPs from different sets of populations.
A boot sector computer virus dubbed (c)Brain, one of the first computer viruses in history, [16] was created in 1986 by the Farooq Alvi Brothers in Lahore, Pakistan, reportedly to deter unauthorized copying of the software they had written. [17] [18] Neurochip by Pakistani-Canadian inventor Naweed Syed.
The History of Pakistan prior to its independence in 1947 spans several millennia and covers a vast geographical area known as the Greater Indus region. [1] Anatomically modern humans arrived in what is now Pakistan between 73,000 and 55,000 years ago. [ 2 ]
The Pakistan Historical Society (PHS) is a democratically organized organization founded in 1950.The Society promotes historical research through the publication of research monographs, the compilation and publication of original sources, and their authoritative translations.