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Decidualization is required in some mammalian species where embryo implantation and trophoblast cell invasion of the endometrium occurs, also known as hemochorial placentation. This allows maternal blood to come into direct contact with the fetal chorion , a membrane between the fetal and maternal tissues, and allows for nutrient and gas exchange.
Experimentally, human endometrial stromal cells can be decidualized in culture by using analogs of cAMP and progesterone. The cells will exhibit a decidualized phenotype and display upregulation of common decidualization markers such as prolactin and IGFBP1 .
Decidualization includes the process of differentiation of the spindle-shape stromal fibroblasts into the plump secretory decidual cells, which create a pericellular extracellular matrix rich in fibronectin and laminin (similar to epithelial cells). Vascularity, as well as vascular permeability, is enhanced in the decidualizing endometrium.
In women of reproductive age, two layers of endometrium can be distinguished. These two layers occur only in the endometrium lining the cavity of the uterus, and not in the lining of the fallopian tubes where a potentially life-threatening ectopic pregnancy may occur nearby.
Menstruation is the shedding of the uterine lining (endometrium). It occurs on a regular basis in uninseminated [ 1 ] sexually reproductive-age females of certain mammal species. Although there is some disagreement in definitions between sources, menstruation is generally considered to be limited to primates .
The endometrium increases thickness, becomes vascularized and its glands grow to be tortuous and boosted in their secretions. These changes reach their maximum about seven days after ovulation. [citation needed] Furthermore, the surface of the endometrium produces a kind of rounded cells, which cover the whole area toward the uterine cavity.
Ormeloxifene also suppresses proliferation and decidualization of the endometrium (the transformation of the endometrium in preparation for possible implantation of an embryo). [32] While they are believed to prevent implantation rather than fertilization, exactly how these effects operate to prevent pregnancy is not understood
Menstrual cycle The menstrual cycle is a series of natural changes in hormone production and the structures of the uterus and ovaries of the female reproductive system that makes pregnancy possible. The ovarian cycle controls the production and release of eggs and the cyclic release of estrogen and progesterone. The uterine cycle governs the preparation and maintenance of the lining of the ...