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The gene that codes for pancreatic elastase 1 is CELA1 (synonym: ELA1) Pancreatic elastase 1 is encoded by a single genetic locus on chromosome 12. Studies of human pancreatic elastase 1 have shown that this serine protease maps to the chromosomal region 12q13 [ 10 ] and it is close to a locus for an autosomal dominant skin disease, Diffuse ...
The fecal elastase test measures the concentration of the elastase-3B enzyme found in fecal matter with an enzyme-linked immunosorbent assay . Results of this test can give a good indication of exocrine pancreatic status, and the test is less invasive and expensive than the current "gold standard", secretin-cholecystokinin test. [9] Levels of ...
Chymotrypsin-like elastase family member 1 (CELA1) also known as elastase-1 (ELA1) is an enzyme that in humans is encoded by the CELA1 gene. Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A ...
The latter is a less used test that assesses exocrine function in the pancreas by inserting a tube into the small intestine to collect pancreatic secretions. The fecal elastase test is a less cumbersome test that has replaced the 72-hour fecal fat test; in the fecal elastase test, pancreatic enzyme replacement therapy (enzyme supplementation ...
A fecal pH test may be used to determine lactose intolerance or the presence of an infection. [13] Steatorrhea can be diagnosed using a fecal fat test, which checks for the malabsorption of fat. [14] Faecal elastase levels are becoming the mainstay of pancreatitis diagnosis.
However, a number of diseases of the pancreas and gastrointestinal tract are characterized by fat malabsorption. Examples of such diseases are: disorders of exocrine pancreatic function, such as chronic pancreatitis, cystic fibrosis and Shwachman–Diamond syndrome (these are characterized by deficiency of pancreatic digestive enzymes)
In chronic pancreatitis, the fecal pancreatic elastase-1 (FPE-1) test is a marker of exocrine pancreatic function. Additional tests that may be useful in evaluating chronic pancreatitis include hemoglobin A1C , immunoglobulin G4 , rheumatoid factor , and anti-nuclear antibody .
Note that "pancreatic elastase 1" is, in fact, not found in the pancreas, but produced in the skin. [5] "Pancreatic elastase 1" (CELA1) is expressed in skin keratinocytes. [6] Neutrophil elastase breaks down the Outer membrane protein A (OmpA) of E. coli and other Gram-negative bacteria, killing the bacterium carrying the protein. [7]