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Clostridium perfringens is a common cause of food poisoning in the United States. C. perfringens produces spores, and when these spores are consumed, they produce a toxin that causes diarrhea. Foods cooked in large batches and held at unsafe temperatures (between 40°F and 140°F) are the source of C. perfringens food poisoning outbreaks.
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This toxin has been shown to be the key virulence factor in infection with C. perfringens; the bacterium is unable to cause disease without this toxin. [1] Further, vaccination against the alpha toxin toxoid protects mice against C. perfringens gas gangrene. [2]
Most species of the genus Clostridium are saprophytic organisms that ferment plant polysaccharides [2] and are found in many places in the environment, most notably the soil. However, the genus does contain some human pathogens (outlined below). The toxins produced by certain members of the genus Clostridium are among
Enterotoxemia is a condition induced by the absorption of large volumes of toxins produced by bacteria such as Clostridium perfringens from the intestines. [1] There are several strains of C. perfringens (type B, C, and D) that may lead to the development of this gastrointestinal condition. [citation needed]
Clostridium perfringens causes a wide range of symptoms, from food poisoning to cellulitis, fasciitis, necrotic enteritis and gas gangrene. [16] [17] Clostridium tetani causes tetanus. Several more pathogenic species, that were previously described in Clostridium, have been found to belong to other genera. [6]
Genus Romboutsia: Clostridium lituseburense, reassugned in 2014. Genus Sarcina: Clostridium maximum and C. ventriculi. Originally described in Sarcina, proposed to be moved to Clostridium in 2016 but remained due to Sarcina being the older genus. Genus Terrisporobacter: Clostridium glycolicum and C. mayombei, reassigned in 2014. Family ...
The AB toxins are two-component protein complexes secreted by a number of pathogenic bacteria, though there is a pore-forming AB toxin found in the eggs of a snail. [1] They can be classified as Type III toxins because they interfere with internal cell function. [2]