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Nikolsky's sign is a clinical dermatological sign, named after Pyotr Nikolsky (1858–1940), a Russian physician who trained and worked in the Russian Empire. The sign is present when slight rubbing of the skin results in exfoliation of the outermost layer.
Nikolsky's sign (gentle lateral pressure) on unaffected mucosa or skin raises a bulla. If no lesions are present on examination it may be useful way of demonstrating reduced epithelial adhesion. If no lesions are present on examination it may be useful way of demonstrating reduced epithelial adhesion.
SSSS is a clinical diagnosis. This is sometimes confirmed by isolation of S. aureus from blood, mucous membranes, or skin biopsy; however, these are often negative. Skin biopsy may show separation of the superficial layer of the epidermis (intraepidermal separation), differentiating SSSS from TEN, wherein the separation occurs at the dermo-epidermal junction (subepidermal separation).
The diagnosis is based on involvement of less than 10% of the skin. [2] It is known as TEN when more than 30% of the skin is involved and an intermediate form with 10 to 30% involvement. [3] A positive Nikolsky's sign is helpful in the diagnosis of SJS and TEN. [9] A skin biopsy is helpful, but not required, to establish a diagnosis of SJS and ...
Psoriasis is classified as a papulosquamous disorder and is most commonly subdivided into different categories based on histological characteristics. [3] [11] Variants include plaque, pustular, guttate, and flexural psoriasis. Each form has a dedicated ICD-10 code. [62] Psoriasis can also be classified into nonpustular and pustular types. [63]
Meghan Markle, the Duchess of Sussex, reportedly earned a nickname from ex Spotify employees inspired by the character of a camp classic film starring Joan Crawford.
The two New York Yankees fans who became infamous figures for interfering with Los Angeles Dodgers outfielder Mookie Betts in Game 4 of the 2024 World Series have been banned indefinitely from ...
This category reflects the organization of International Statistical Classification of Diseases and Related Health Problems, 10th Revision. Generally, diseases outlined within the ICD-10 codes R20-R23 within Chapter XVIII: Symptoms, signs and abnormal clinical and laboratory findings should be included in this category.
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