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The benzimidazole compounds albendazole (brand names e.g., Albenza, Eskazole, Zentel and Andazol) and mebendazole (brand names e.g., Ovex, Vermox, Antiox and Pripsen) are the most effective. [26] They work by inhibiting the microtubule function in the pinworm adults, causing glycogen depletion, [26] thereby effectively starving the parasite. [27]
In a recent comparative study, thiabendazole at a higher activity than single drug treatments such as ivermectin, DEC, and mebendazole, but lower activity than the combined regimen of mebendazole and DEC. [3] However, more research may be needed into confirm the correct dosage and true effectiveness of thiabendazole in combating M. perstans ...
Albendazole is a broad-spectrum antihelmintic and antiprotozoal agent of the benzimidazole type. [3] It is used for the treatment of a variety of intestinal parasite infections, including ascariasis, pinworm infection, hookworm infection, trichuriasis, strongyloidiasis, taeniasis, clonorchiasis, opisthorchiasis, cutaneous larva migrans, giardiasis, and gnathostomiasis, among other diseases.
Mebendazole has a much higher failure rate in clinical practice than albendazole or ivermectin. [25] However, these drugs have little effect on the autoinfective larvae. Hence, repeat treatments with ivermectin or albendazole must be administered to kill newly matured parasites that have developed from the autoinfective larvae.
Single-dose of albendazole, mebendazole, and ivermectin are effective against ascariasis. They are effective at removing parasites and eggs from the intestines. [35] Other effective agents include tribendimidine and nitazoxanide. [2] Pyrantel pamoate may induce intestinal obstruction in a heavy worm load.
Mebendazole (MBZ), sold under the brand name Vermox among others, is a medication used to treat a number of parasitic worm infestations. [5] This includes ascariasis , pinworm infection , hookworm infections , guinea worm infections and hydatid disease , among others. [ 5 ]
The risk of infection can be reduced on an individual level by not walking barefoot in areas where the disease is common. At a population level, decreasing outdoor defecation, not using raw feces as fertilizer, and mass deworming are effective. [1] Treatment is typically with the medications albendazole or mebendazole for one to three days.
The efficacy of single-dose treatments for hookworm infections were: 72% for albendazole, 15% for mebendazole, and 31% for pyrantel pamoate. [18] A current concern with this parasite is the increase in drug resistance, such as benzimidazoles and mebendazoles. [19] Pregnant women should not be treated within their first trimester. [9]