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It is now considered the first-line prevention and treatment for hypertrophic and keloid scars by occlusion and then hydration of the scar tissue. [3] Silicone gel is made of medical-grade silicone polymers. [4] Silicone gel sheet consists of a soft, semi-occlusive sheet and a membrane that increases the durability of the sheet. [3] The sheet ...
These clear silicone sheets have an adhesive that mimics the natural skin barrier and provides a moist environment, which allows the scar to heal better, according to Dr. Marisa Garshick, a board ...
Verapamil, a type of calcium channel blocker, is considered a candidate drug for the treatment of hypertrophic scars. A study conducted by the Catholic University of Korea concluded that verapamil-releasing silicone gel is effective and is a superior alternative to the conventional silicone gel where decreased median SEI, fibroblast count, and ...
A hypertrophic scar is a cutaneous condition characterized by deposits of excessive amounts of collagen which gives rise to a raised scar, but not to the degree observed with keloids. [1] Like keloids, they form most often at the sites of pimples, body piercings , cuts and burns.
In severe cases, it can affect movement of skin. In the United States, keloid scars are seen 15 times more frequently in people of sub-Saharan African descent than in people of European descent. [3] There is a higher tendency to develop a keloid among those with a family history of keloids and people between the ages of 10 and 30 years. [4]
A 2006 clinical trial found no statistically significant change in hypertrophic scar appearance from products of this type compared to the standard petrolatum emollient. [6] According to a 2011 Los Angeles Times article, "there were just two randomized comparison trials of Mederma, with a combined total of 38 participants. Neither trial found ...