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Targeted temperature management (TTM), previously known as therapeutic hypothermia or protective hypothermia, is an active treatment that tries to achieve and maintain a specific body temperature in a person for a specific duration of time in an effort to improve health outcomes during recovery after a period of stopped blood flow to the brain. [1]
By controlling the temperature of the water running through the gel pads, the Arctic Sun can help regulate a patient's body temperature. Controlled rewarming has been cited in the literature as beneficial in preventing reperfusion injury. A complaint levied against the Arctic Sun is the risk of skin injury.
Passive external rewarming involves the use of a person's own ability to generate heat by providing properly insulated dry clothing and moving to a warm environment. [66] Passive external rewarming is recommended for those with mild hypothermia. [66] Active external rewarming involves applying warming devices externally, such as a heating ...
Excessive rewarming with temperatures above 37 °C can increase the risk of cerebral ischemia secondary to the increased oxygen demand that occurs with rapid rewarming. [2] Several theories have been proposed, with one being during re-warming, the body releases increasing catecholamines which increase heat production leading to a loss of ...
Afterdrop is a continued cooling of core temperature during the initial stages of rewarming from hypothermia.. Afterdrop is attributed to the return of cold blood from extremities to the core due to peripheral vasodilatation, thus causing a further decrease of deep body temperature. [1]
The sponsor is responsible for designing a CRF that accurately represents the protocol of the clinical trial, as well as managing its production, monitoring the data collection and auditing the content of the filled-in CRFs. Case report forms contain data obtained during the patient's participation in the clinical trial.
The Common Technical Document (CTD) is a set of specifications for an application dossier for the registration of medicine, designed for use across Europe, Japan, the United States, and beyond. [ 1 ] Major Synopsis
Rewarming shock (also known as rewarming collapse) has been described as a drop in blood pressure following the warming of a person who is very cold. [1] The real cause of this rewarming shock is unknown. [1] There was a theoretical concern that external rewarming rather than internal rewarming may increase the risk. [2]