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Chloroquine (CQ) then becomes protonated (to CQ 2+), as the digestive vacuole is known to be acidic (pH 4.7); chloroquine then cannot leave by diffusion. Chloroquine caps hemozoin molecules to prevent further biocrystallization of heme, thus leading to heme buildup. Chloroquine binds to heme (or FP) to form the FP-chloroquine complex; this ...
Calymmatobacterium granulomatis; Campylobacter. Campylobacter coli; Campylobacter fetus; Campylobacter jejuni; Campylobacter pylori; Capnocytophaga canimorsus
Chloroquine and hydroxychloroquine are anti-malarial medications also used against some auto-immune diseases. [1] Chloroquine, along with hydroxychloroquine, was an early experimental treatment for COVID-19. [2] Neither drug has been useful to prevent or treat SARS-CoV-2 infection.
Narrow-spectrum antibiotics have low propensity to induce bacterial resistance and are less likely to disrupt the microbiome (normal microflora). [3] On the other hand, indiscriminate use of broad-spectrum antibiotics may not only induce the development of bacterial resistance and promote the emergency of multidrug-resistant organisms, but also cause off-target effects due to dysbiosis.
Fosfomycin is an antimicrobial agent that acts to inhibit UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) which catalyzes one of the early steps of bacterial cell wall synthesis, and is effective against gram-negative and -positive aerobic bacteria, such as CRE. A meta-analysis of 17 studies investigating the clinical effectiveness of ...
Chloroxine (trade name Capitrol; Kloroxin, Dichlorchinolinol, chlorquinol, halquinol(s)); [citation needed] Latin cloroxinum, dichlorchinolinolum) is an antibacterial drug. [1]
A variety of derivatives of 4-aminoquinoline are antimalarial agents useful in treating erythrocytic plasmodial infections. [2] Examples include amodiaquine, chloroquine, and hydroxychloroquine. [3] Other uses for the derivatives are: anti-asthmatic, antibacterial, anti-fungal, anti-malarial, antiviral and anti-inflammatory agents. [1]
A member of the human microbiome, Eikenella corrodens is a commensal bacterial species found in the mouth and upper respiratory tract.It is an unusual cause of infection and when it is cultured, it is most usually found mixed with other organisms.