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A galactagogue, or galactogogue (from Greek: γάλα [γαλακτ-], milk, + ἀγωγός, leading), also known as a lactation inducer or milk booster, is a substance that promotes lactation in humans and other animals. [1] [2] It may be synthetic, plant-derived, or endogenous. They may be used to induce lactation and to treat low milk supply.
A 2018 meta-analysis of five randomized controlled trials found that domperidone resulted in a moderate increase of in breast milk volume for mothers of preterm infants with insufficient milk supply. The analysis also indicated that domperidone was well tolerated with no significant difference in maternal adverse events compared to placebo. [35]
Galactagogues increase milk supply, although even herbal variants carry risks. Non-pharmaceutical methods should be tried first, such as pumping out the mother's breast milk supply often, warming or massaging the breast, as well as starting milk pumping earlier after the child is born if they cannot drink milk at the breast. [41] [42] [43] [44]
A sharp increase in citrate and lactose concentration; [8] [9] Plasma α-lactalbumin levels peak; [8] and; Decreased breast milk sodium concentration. [10] [11] Note that delayed onset of lactogenesis II is distinct from low milk supply, where there is a normal onset of lactation, but breast milk is produced in small and insufficient amounts. [12]
Hyperlactation syndrome is a condition where breast milk overflow occurs because of increased milk production. [1] The milk may come out fast and forcibly, making it difficult for the baby to nurse well. [2] Symptoms for the mother include breasts that never feel soft and comfortable, even after feeding, mastitis, blocked ducts and sore nipples.
Metoclopramide is a medication used to treat nausea, vomiting, gastroparesis, and gastroesophageal reflux disease. [5] It is also used to treat migraine headaches. [6]Common side effects include feeling tired, diarrhea, akathisia, and tardive dyskinesia.
The forceful spray of milk can cause the baby to consume too much milk too quickly as well as to swallow air during the period of rapid swallowing following the let-down. The speed of the flow of milk into the mouth can cause the baby to react with reduced nursing times and aversion to nursing often described by mothers as "fussiness ...
The anti-inflammatory components in breast milk are those bioactive substances that confer or increase the anti-inflammatory response in a breastfeeding infant. [ 1 ] Anti-inflammatory Components of Breastmilk