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The design of experiments (DOE), [1] also known as experiment design or experimental design, is the design of any task that aims to describe and explain the variation of information under conditions that are hypothesized to reflect the variation.
Protein folding problem: Is it possible to predict the secondary, tertiary and quaternary structure of a polypeptide sequence based solely on the sequence and environmental information? Inverse protein-folding problem: Is it possible to design a polypeptide sequence which will adopt a given structure under certain environmental conditions?
In the design of experiments, a between-group design is an experiment that has two or more groups of subjects each being tested by a different testing factor simultaneously. This design is usually used in place of, or in some cases in conjunction with, the within-subject design , which applies the same variations of conditions to each subject ...
In some cases, simply doing a reverse titration of changing the samples between the injection syringe and sample cell can solve the issue, depending on the binding mechanism. However, the process of introducing a ligand to a macromolecule is distinct from the process of adding a macromolecule to a ligand. [ 15 ]
1989: Thomas R. Cech (Colorado) and Sidney Altman (Yale) won the Nobel Prize in chemistry for their independent discovery in the 1980s of ribozymes – for the "discovery of catalytic properties of RNA" – using different approaches. Catalytic RNA was an unexpected finding, something they were not looking for, and it required rigorous proof ...
It is possible to have multiple independent variables or multiple dependent variables. For instance, in multivariable calculus, one often encounters functions of the form z = f(x,y), where z is a dependent variable and x and y are independent variables. [8] Functions with multiple outputs are often referred to as vector-valued functions.
For every physically independent process (Prigogine & Defay, p. 38; Prigogine, p. 24) ˙. This is a remarkable result since the chemical potentials are intensive system variables, depending only on the local molecular milieu.
In physical chemistry and chemical engineering, extent of reaction is a quantity that measures the extent to which the reaction has proceeded. Often, it refers specifically to the value of the extent of reaction when equilibrium has been reached.