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Myelin basic protein (MBP) is a protein believed [weasel words] to be important in the process of myelination of nerves in the nervous system. The myelin sheath is a multi-layered membrane, unique to the nervous system, that functions as an insulator to greatly increase the velocity of axonal impulse conduction . [ 5 ]
In terms of total mass, myelin comprises approximately 40% water; the dry mass comprises between 60% and 75% lipid and between 15% and 25% protein. Protein content includes myelin basic protein (MBP), [21] which is abundant in the CNS where it plays a critical, non-redundant role in formation of compact myelin; myelin oligodendrocyte ...
In enzymology, a [myelin basic protein]-arginine N-methyltransferase (EC 2.1.1.126) is an enzyme that catalyzes the chemical reaction S-adenosyl-L-methionine + [myelin basic protein]-arginine ⇌ {\displaystyle \rightleftharpoons } S-adenosyl-L-homocysteine + [myelin basic protein]-Nomega-methyl-arginine
Myelin basic protein is the antigen in the myelin sheaths of the neurons that stimulates an autoimmune reaction in people with MS, so the peptide may work as a decoy for the attacking immune cells. Glatiramer acetate was originally discovered at the Weizmann Institute of Science. It is on the World Health Organization's List of Essential ...
The insulation must be proportional to the diameter of the fibre inside. The optimal ratio of axon diameter divided by the total fiber diameter (which includes the myelin) is 0.6. [24] Oligodendrocytes in rat cerebellum stained with antibody to myelin basic protein in red and for DNA in blue. Two oligodendrocyte cell bodies are clearly visible ...
The crystal structure of myelin oligodendrocyte glycoprotein was determined by x-ray diffraction at a resolution of 1.45 Angstroms, using protein from the Norway rat. This protein is 139 residues long, and is a member of the immunoglobulin superfamily. [ 13 ]
Myelin proteolipid protein (PLP or lipophilin) [1] is the major myelin protein from the central nervous system (CNS). It plays an important role in the formation or ...
Milk basic protein, a milk protein fraction; Myc-binding protein-1, a protein encoded by the alpha-enolase glycolytic enzyme; Myelin basic protein, a protein believed to be important in the process of myelination of nerves in the central nervous system; Mannan-binding lectin (also mannose- or mannan-binding protein), an important factor in ...