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Chloroquine (CQ) then becomes protonated (to CQ 2+), as the digestive vacuole is known to be acidic (pH 4.7); chloroquine then cannot leave by diffusion. Chloroquine caps hemozoin molecules to prevent further biocrystallization of heme, thus leading to heme buildup. Chloroquine binds to heme (or FP) to form the FP-chloroquine complex; this ...
Perianal cellulitis, also known as perianitis or perianal streptococcal dermatitis, is a bacterial infection affecting the lower layers of the skin around the anus. [1] [2] [3] It presents as bright redness in the skin and can be accompanied by pain, difficulty defecating, itching, and bleeding.
Proctocolitis has many possible causes. Common infectious causes of proctocolitis include Chlamydia trachomatis, LGV (Lymphogranuloma venereum), Neisseria gonorrhoeae, HSV, and Helicobacter species. It can also be idiopathic (see colitis), vascular (as in ischemic colitis), or autoimmune (as in inflammatory bowel disease). [citation needed]
A stool culture is used to detect the presence of disease-causing bacteria (pathogenic) and help diagnose an infection of the digestive tract. In the case of staphylococcal enteritis, it is conducted to see if the stool is positive for a pathogenic bacterium. [1]
The cause of dysentery is usually the bacteria from genus Shigella, in which case it is known as shigellosis, or the amoeba Entamoeba histolytica; then it is called amoebiasis. [1] Other causes may include certain chemicals, other bacteria, other protozoa, or parasitic worms. [2] It may spread between people. [4]
Giardiasis is caused by the protozoan Giardia duodenalis. [16] The infection occurs in many animals, including beavers, other rodents, cows, and sheep. [16] Animals are believed to play a role in keeping infections present in an environment. [16] G. duodenalis has been sub-classified into eight genetic assemblages (designated A–H). [17]
For example, the physician may prescribe antibiotics for proctitis caused by bacterial infection. If the proctitis is caused by Crohn's disease or ulcerative colitis, the physician may prescribe the drug 5-aminosalicyclic acid (5ASA) or corticosteroids applied directly to the area in enema or suppository form, or taken orally in pill form.
Phocaeicola vulgatus, (formerly Bacteroides vulgatus), [1] is a mutualistic anaerobic Gram negative rod bacteria commonly found in the human gut microbiome and isolated from feces. [2] P. vulgatus has medical relevance and has been notable in scientific research due to its production of fatty acids , potential use as a probiotic , and ...