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The first case of spongy degeneration of the CNS was reported in 1928 by Globus and Strauss, [42] who designated the case as Schilder's disease, a term for diffuse myelinoclastic sclerosis. [43] [44] [45] In 1931, Canavan reported a case where the megalencephaly of brain degeneration is different from that caused by a tumour. [46]
Canavan disease, or Canavan–Van Bogaert–Bertrand disease, is a rare and fatal autosomal recessive [1] degenerative disease that causes progressive damage to nerve cells and loss of white matter in the brain. [2] It is one of the most common degenerative cerebral diseases of infancy. [3]
The plaintiffs in this case were a group of parents of children who had Canavan disease and three non-profit organizations who developed a confidential Canavan disease registry and database. [1] The parents provided their children's tissue for research on the disease and the non-profit groups aided in the identification of other affected ...
Myrtelle May Moore Canavan [1] (June 24, 1879 – August 4, 1953) was an American physician and medical researcher. She was one of the first female pathologists and is best known for publishing a description of Canavan disease in 1931.
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CNS demyelination autoimmune disease causes the myelin sheath to deteriorate since the sense of recognition of self is lost. The loss of the myelin insulation either disrupts or prevents neural conduction along the nerve cell's axon.
Fern Kupfer. Fern Lee Kupfer is an American author and retired professor of creative writing at Iowa State University.She has written several novels and as well as memoirs reflecting on her life experiences, the discovery that she is a carrier of the BRCA gene, and the loss of her son to Canavan disease.
Katherine Canavan, United States diplomat and career foreign service officer; Matt Canavan, Australian Federal MP; Michael Noel Canavan, Irish police officer, recipient of the Scott Medal; Myrtelle Canavan, American pathologist who described Canavan disease in 1931; Niall Canavan, Irish footballer; Pascal Canavan, Tyrone Gaelic footballer