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Several parameters can be calculated for each loop (e.g. end-diastolic pressure, end-systolic pressure, ejection and filling intervals, contractility index, stroke volume, and ejection fraction). More importantly, other interesting parameters are derived from series of loops obtained under changing conditions.
The path between each state consists of some process (A through D) which alters the pressure or volume of the system (or both). Generalized PV diagram A key feature of the diagram is that the amount of energy expended or received by the system as work can be measured because the net work is represented by the area enclosed by the four lines.
Pressure-Volume loops showing end-systolic pressure volume relationship. End-systolic pressure volume relationship (ESPVR) describes the maximal pressure that can be developed by the ventricle at any given LV volume. This implies that the PV loop cannot cross over the line defining ESPVR for any given contractile state.
Wiggers diagram with mechanical (echo), electrical (ECG), and aortic pressure (catheter) waveforms, together with an in-ear dynamic pressure waveform measured using a novel infrasonic hemodynography technology, for a patient with severe aortic stenosis. Modified from [3]
For example, if a person’s actual blood pressure is 134, and blood pressure is measured on a dangling arm, the reading could end up over 140, which is considered to be stage 2 hypertension.
Cardiac (ventricular) systole: Both AV valves (tricuspid in the right heart (light-blue), mitral in the left heart (pink)) are closed by back-pressure as the ventricles are contracted and their blood volumes are ejected through the newly-opened pulmonary valve (dark-blue arrow) and aortic valve (dark-red arrow) into the pulmonary trunk and ...
Venous return (VR) is the flow of blood back to the heart. Under steady-state conditions, venous return must equal cardiac output (Q), when averaged over time because the cardiovascular system is essentially a closed loop. Otherwise, blood would accumulate in either the systemic or pulmonary circulations.
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