Ad
related to: 6 phosphofructo 2 kinase deficiency
Search results
Results From The WOW.Com Content Network
This enzyme's main function is to synthesize or degrade allosteric regulator Fru-2,6-P 2 in response to glycolytic needs of the cell or organism, as depicted in the accompanying diagram. PFK-2 and FBPase-2 Reaction. In enzymology, a 6-phosphofructo-2-kinase (EC 2.7.1.105) is an enzyme that catalyzes the chemical reaction:
Phosphofructokinase catalyses the phosphorylation of fructose-6-phosphate to fructose-1,6-bisphosphate, a key regulatory step in the glycolytic pathway. [ 2 ] [ 3 ] It is allosterically inhibited by ATP and allosterically activated by AMP , thus indicating the cell's energetic needs when it undergoes the glycolytic pathway. [ 4 ]
Phosphofructokinase deficiency; Other names: Glycogen storage disease type VII or Tarui's disease [1] [2] A rendering of the human muscular form of phosphofructokinase. Mutations in the production of this enzyme are the cause of Tarui's disease. [3] The symmetry of the enzyme is a result of its tetrameric structure. Specialty: Endocrinology ...
6-phosphofructokinase, liver type (PFKL) is an enzyme that in humans is encoded by the PFKL gene on chromosome 21. [5] This gene encodes the liver (L) isoform of phosphofructokinase-1 , an enzyme that catalyzes the conversion of D - fructose 6-phosphate to D - fructose 1,6-bisphosphate , which is a key step in glucose metabolism ( glycolysis ).
6-phosphofructokinase, muscle type is an enzyme that in humans is encoded by the PFKM gene on chromosome 12. Three phosphofructokinase isozymes exist in humans: muscle, liver and platelet . These isozymes function as subunits of the mammalian tetramer phosphofructokinase, which catalyzes the phosphorylation of fructose-6-phosphate to fructose-1 ...
The F-2,6-BP active site structurally open, while the active pocket of 6-phosphofructo-2-kinase is more rigid. This rigidity permits the independent binding of F-6-P and ATP with increased affinity than other isoforms.
The protein encoded by this gene is involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate, and a fructose-2,6-biphosphatase activity that ...
The bifunctional 6-phosphofructo-2-kinase (EC 2.7.1.105)/fructose-2,6-bisphosphatase (EC 3.1.3.46) (PFKFB) regulates the steady-state concentration of fructose 2,6-bisphosphate, an activator of a key regulatory enzyme of glycolysis, phosphofructokinase.