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Fructose 2,6-bisphosphate, abbreviated Fru-2,6-P 2, is a metabolite that allosterically affects the activity of the enzymes phosphofructokinase 1 (PFK-1) and fructose 1,6-bisphosphatase (FBPase-1) to regulate glycolysis and gluconeogenesis.
beta-D-fructose 2,6-bisphosphate + H 2 O D-fructose 6-phosphate + phosphate [18] Because of the enzyme's dual functions, it can be categorized into multiple families. Through categorization by the kinase reaction, this enzyme belongs to the family of transferases , specifically those transferring phosphorus-containing groups ...
PFK1 is allosterically activated by a high concentration of AMP, but the most potent activator is fructose 2,6-bisphosphate, which is also produced from fructose-6-phosphate by PFK2. Hence, an abundance of F6P results in a higher concentration of fructose 2,6-bisphosphate (F-2,6-BP). The binding of F-2,6-BP increases the affinity of PFK1 for ...
The enzyme fructose-2,6-bisphosphate 2-phosphatase ({EC 3.1.3.46) catalyzes the reaction . β-D-fructose 2,6-bisphosphate + H 2 O D-fructose 6-phosphate + phosphateThis enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds.
This protein regulates fructose-2,6-bisphosphate levels in the heart, while a related enzyme encoded by a different gene regulates fructose-2,6-bisphosphate levels in the liver and muscle. This enzyme functions as a homodimer. Two transcript variants encoding two different isoforms have been found for this gene. [5]
Fructose-2,6-bisphosphate 6-phosphatase (EC 3.1.3.54), an enzyme that catalyzes the chemical reaction beta-D-fructose 2,6-bisphosphate + H 2 O beta-D-fructofuranose 2-phosphate + phosphate; Glucose-1,6-bisphosphate synthase, a type of enzyme called a phosphotransferase and is involved in mammalian starch and sucrose metabolism
Function [ edit ] The bifunctional 6-phosphofructo-2-kinase ( EC 2.7.1.105 )/fructose-2,6-bisphosphatase ( EC 3.1.3.46 ) (PFKFB) regulates the steady-state concentration of fructose 2,6-bisphosphate , an activator of a key regulatory enzyme of glycolysis , phosphofructokinase .
14120 Ensembl ENSG00000130957 ENSMUSG00000021456 UniProt O00757 P70695 RefSeq (mRNA) NM_003837 NM_007994 RefSeq (protein) NP_003828 NP_032020 Location (UCSC) Chr 9: 94.56 – 94.59 Mb Chr 13: 62.98 – 63.01 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Fructose-bisphosphatase 2 is an enzyme that in humans is encoded by the FBP2 gene. Function This gene encodes a gluconeogenesis ...