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Systemic Therapy in Advancing or Metastatic Prostate Cancer: Evaluation of Drug Efficacy (STAMPEDE) is a clinical trial investigating treatments for high risk or terminal prostate cancer. Recruitment started in 2005 and ended in 2022; as of January 2020, over 10,000 participants had joined the trial.
Besides the PATCH trial, the Systemic Therapy in Advancing or Metastatic Prostate Cancer: Evaluation of Drug Efficacy (STAMPEDE) trial, also in the United Kingdom, added a high-dose transdermal estradiol patches arm with approximately 2,000 men in July 2017. [5] [2] [3]
Androgen deprivation therapy (ADT), also called androgen ablation therapy or androgen suppression therapy, is an antihormone therapy whose main use is in treating prostate cancer. Prostate cancer cells usually require androgen hormones, such as testosterone, to grow.
Experimental cancer treatments are normally available only to people who participate in formal research programs, which are called clinical trials. Occasionally, a seriously ill person may be able to access an experimental drug through an expanded access program. Some of the treatments have regulatory approval for treating other conditions.
The patent protection of bicalutamide expired in the U.S. in March 2009 and the drug has subsequently been available as a generic, [292] at greatly reduced cost. [ 293 ] Bicalutamide was the fourth antiandrogen (and the third NSAA ) to be introduced for the treatment of prostate cancer, following the SAA CPA in 1973 [ 294 ] and the NSAAs ...
The candidate, JANX007, reduced prostate-specific (PSA) antigen levels in a majority of the 23 patients who received the drug, the company said late on Monday, adding that deeper reductions were ...
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