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On the contrary, leptin expression was increased, proposing the possibility of leptin-resistance in human obesity. [3] Since this discovery, many other hormonal mechanisms have been elucidated that participate in the regulation of appetite and food intake, storage patterns of adipose tissue , and development of insulin resistance .
Adipose tissue is an endocrine organ that secretes numerous protein hormones, including leptin, adiponectin, and resistin. [1] These hormones generally influence energy metabolism, which is of great interest to the understanding and treatment of type 2 diabetes and obesity.
Leptin receptors are expressed not only in the hypothalamus but also in other brain regions, particularly in the hippocampus. Thus some leptin receptors in the brain are classified as central (hypothalamic) and some as peripheral (non-hypothalamic). As scientifically known so far, the general effects of leptin in the central nervous system are:
As of 2016, 1.9 billion adults (aged 18 years or older) were classified as being overweight, and within these adults, 650 million were classified as obese. [6] This translates to 39% of adults (39% of men and 40% of women) being overweight and 13% of the adult population worldwide (11% of men and 15% of women) being obese in 2016.
A prominent example of the gut–memory connection is the effects that alterations in the gut microbiome can have on the pathogenesis of neural diseases like Alzheimer's. [ 3 ] Understanding the connections between the gut microbiome and cognitive health could aid researchers in developing novel strategies for slowing down cognitive decline in ...
Losing weight after 40: A group of medical professionals is urging doctors to regularly weigh patients that are women ages 40 to 60, but some aren't happy.
A new study found that taking vitamin D supplements was associated with lower blood pressure. People with obesity and high blood pressure got the best results.
In June 2021, the US Food and Drug Administration (FDA) approved semaglutide injection sold under the brand name Wegovy for long-term weight management in adults. It is associated with a loss of 6-12% body weight along with mild gastrointestinal side effects. [10] [11] Another medication, orlistat, is widely available and approved for long-term ...
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