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Hsp90 (heat shock protein 90) is a chaperone protein that assists other proteins to fold properly, stabilizes proteins against heat stress, and aids in protein degradation. It also stabilizes a number of proteins required for tumor growth, which is why Hsp90 inhibitors are investigated as anti-cancer drugs.
Chaperonins are characterized by their barrel-shaped structure with binding sites for client proteins inside the barrels. The human HSP90 group consists of 5 members according to the HGNC: [17] [18] HSP90AA1 (heat shock protein 90 kDa alpha, class A, member 1) HSP90AA3P (heat shock protein 90 alpha family class A member 3, pseudogene)
3320 15519 Ensembl ENSG00000080824 ENSMUSG00000021270 UniProt P07900 P07901 RefSeq (mRNA) NM_001017963 NM_005348 NM_010480 RefSeq (protein) NP_001017963 NP_005339 NP_034610 Location (UCSC) Chr 14: 102.08 – 102.14 Mb Chr 12: 110.66 – 110.67 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Heat shock protein HSP 90-alpha is a protein that in humans is encoded by the HSP90AA1 gene ...
22027 Ensembl ENSG00000166598 ENSMUSG00000020048 UniProt P14625 P08113 RefSeq (mRNA) NM_003299 NM_011631 RefSeq (protein) NP_003290 NP_035761 Location (UCSC) Chr 12: 103.93 – 103.95 Mb Chr 10: 86.53 – 86.54 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Heat shock protein 90kDa beta member 1 (HSP90B1), known also as endoplasmin, gp96, grp94, or ERp99, is a chaperone protein that ...
An Hsp90 inhibitor is a substance that inhibits that activity of the Hsp90 heat shock protein.Since Hsp90 stabilizes a variety of proteins required for survival of cancer cells, these substances may have therapeutic benefit in the treatment of various types of malignancies. [2]
Heat shock proteins are named according to their molecular weight. For example, Hsp60, Hsp70 and Hsp90 (the most widely studied HSPs) refer to families of heat shock proteins on the order of 60, 70 and 90 kilodaltons in size, respectively. [7]
217737 Ensembl ENSG00000100591 ENSMUSG00000021037 UniProt O95433 Q8BK64 RefSeq (mRNA) NM_012111 NM_001321441 NM_146036 RefSeq (protein) NP_001308370 NP_036243 NP_666148 Location (UCSC) Chr 14: 77.46 – 77.47 Mb Chr 12: 87.31 – 87.32 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Activator of 90 kDa heat shock protein ATPase homolog 1 is an enzyme that in humans is encoded by the ...
AHSA2 also known as AHA1, activator of heat shock 90kDa protein ATPase homolog 2 (yeast) is a human gene which encodes a protein which acts as co-chaperone of Hsp90 (heat shock protein 90). [1] AHSA2 and the related AHSA1 belongs to the AHA ( A ctivator of H sp90 A TPase) family of stress-regulated proteins that bind directly to Hsp90 and are ...