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The name derives from the 2 rounds of duplication originally hypothesized by Ohno, but refined in a 1994 version, and the term 2R hypothesis was probably coined in 1999. Variations in the number and timings of genome duplications typically still are referred to as examples of the 2R hypothesis.
21973 Ensembl ENSG00000131747 ENSMUSG00000020914 UniProt P11388 Q01320 RefSeq (mRNA) NM_001067 NM_011623 RefSeq (protein) NP_001058 NP_035753 Location (UCSC) Chr 17: 40.39 – 40.42 Mb Chr 11: 98.88 – 98.92 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse DNA topoisomerase IIα is a human enzyme encoded by the TOP2A gene. Topoisomerase IIα relieves topological DNA stress during ...
In humans, chromosomes Y and 22 have the greatest proportion of SDs: 50.4% and 11.9% respectively. [2] SRGAP2 is an SD. Misalignment of LCRs during non-allelic homologous recombination (NAHR) [3] is an important mechanism underlying the chromosomal microdeletion disorders as well as their reciprocal duplication partners. [4]
79009 94213 Ensembl ENSG00000107625 ENSMUSG00000020076 UniProt Q9BQ39 Q99MJ9 RefSeq (mRNA) NM_024045 NM_053183 NM_001358819 NM_001358820 RefSeq (protein) NP_076950 NP_444413 NP_001345748 NP_001345749 Location (UCSC) Chr 10: 68.9 – 68.95 Mb Chr 10: 62.45 – 62.49 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse ATP-dependent RNA helicase DDX50 is an enzyme that in humans is encoded ...
3181 53379 Ensembl ENSG00000122566 ENSMUSG00000004980 UniProt P22626 O88569 RefSeq (mRNA) NM_002137 NM_031243 NM_016806 NM_182650 RefSeq (protein) NP_002128 NP_112533 NP_058086 NP_872591 NP_001361674 Location (UCSC) Chr 7: 26.17 – 26.2 Mb Chr 6: 51.46 – 51.47 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Heterogeneous nuclear ribonucleoproteins A2/B1 is a protein that in humans ...
Paleopolyploidy can be identified as massive gene duplication at one time using a molecular clock. To distinguish between whole-genome duplication and a collection of (more common) single gene duplication events, the following rules are often applied: Detection of paleopolyploidy using Ks. Duplicated genes are located in large duplicated blocks.
All tandem repeat arrays are classifiable as satellite DNA, a name originating from the fact that tandem DNA repeats, by nature of repeating the same nucleotide sequences repeatedly, have a unique ratio of the two possible nucleotide base pair combinations, conferring them a specific mass density that allows them to be separated from the rest of the genome with density-based laboratory ...
Gamma-tubulin complex component 2 is a protein that in humans is encoded by the TUBGCP2 gene. [ 5 ] [ 6 ] It is part of the gamma-tubulin complex, which is required for microtubule nucleation at the centrosome .