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Eat-me signals mark the apoptotic cells for phagocytes which can subsequently engulf them and actively prevent the inflammation.Various molecular markers can serve as eat-me signals, particularly a change in composition of the cell membrane, [3] modifications of molecules on the cell surface, changed charge on the plasma membrane, or indirectly the extracellular bridging molecules.
Pathogen-associated molecular patterns (PAMPs) are small molecular motifs conserved within a class of microbes, but not present in the host. [1] They are recognized by toll-like receptors (TLRs) and other pattern recognition receptors (PRRs) in both plants and animals. [ 2 ]
Also called the Blue Dog Democrats or simply the Blue Dogs. A caucus in the United States House of Representatives comprising members of the Democratic Party who identify as centrists or conservatives and profess an independence from the leadership of both major parties. The caucus is the modern development of a more informal grouping of relatively conservative Democrats in U.S. Congress ...
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In contrast to the noninfectious inflammatory response produced by DAMPs, pathogen-associated molecular patterns (PAMPs) initiate and perpetuate the infectious pathogen-induced inflammatory response. [6] Many DAMPs are nuclear or cytosolic proteins with defined intracellular function that are released outside the cell following tissue injury. [7]
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NGP VAN was created in November 2010 by the merger of its two predecessor companies: NGP Software (founded in 1997 by Nathaniel Pearlman, who later served as chief technology officer for Hillary Clinton's 2008 presidential campaign, [6] in his attic in Washington, DC), and Voter Activation Network (founded in 2001 by Mark Sullivan, in his study in Cambridge, Massachusetts).
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