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The cause of pericarditis often remains unknown but is believed to be most often due to a viral infection. [4] [8] Other causes include bacterial infections such as tuberculosis, uremic pericarditis, heart attack, cancer, autoimmune disorders, and chest trauma.
Purulent pericarditis refers to localized inflammation in the setting of infection of the pericardial sac surrounding the heart. [1] In contrast to other causes of pericarditis which may have a viral etiology, purulent pericarditis refers specifically to bacterial or fungal infection of the pericardial sac. [ 2 ]
Cardiac inflammation: idiopathic pericarditis is the most common inflammatory cause of pericardial effusion in the United States. [8] [9] Autoimmune: lupus, rheumatoid arthritis, [10] Sjögren syndrome, scleroderma, Dressler's syndrome, sarcoidosis; Drug hypersensitivity/ side effects: Chemotherapy drugs (doxorubicin and cyclophosphamide ...
The study only documented myocarditis and pericarditis, rare inflammatory heart conditions, in the vaccinated group, but the incidences were very rare − 27 cases per million after the first dose ...
The other 10–20% of acute pericarditis cases have various causes including connective tissue diseases (e.g., systemic lupus erythematosus), cancer, or involve an inflammatory reaction of the pericardium following trauma to the heart such as after a heart attack such as Dressler's syndrome. [2]
Two distinct drug classes in which cardiotoxicity can occur are in anti-cancer and antiarrhythmic drugs. Anti-cancer drug classes that cause cardiotoxicity include anthracyclines, monoclonal antibodies, and antimetabolites. This form generally manifests as a progressive form of heart failure, but can also manifest as an harmful arrhythmia. [2]
Uremic pericarditis is associated with azotemia, and occurs in about 6-10% of kidney failure patients. BUN is normally >60 mg/dL (normal is 7–20 mg/dL). However, the degree of pericarditis does not correlate with the degree of serum BUN or creatinine elevation. The pathogenesis is poorly understood. [2]
A large study published in Nature Medicine reviewed the effects of GLP-1 drugs like Ozempic and Mounjaro on 175 different health outcomes. The findings show benefits for brain and heart health ...