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  2. Avapritinib - Wikipedia

    en.wikipedia.org/wiki/Avapritinib

    Avapritinib, sold under the brand name Ayvakit among others, is a medication used for the treatment of advanced systemic mastocytosis and indolent systemic mastocytosis. It is also used for the treatment of tumors due to one specific rare mutation: it is specifically intended for adults with unresectable or metastatic gastrointestinal stromal tumor (GIST) that harbor a platelet-derived growth ...

  3. Dostarlimab - Wikipedia

    en.wikipedia.org/wiki/Dostarlimab

    Dostarlimab was approved for the treatment of endometrial cancer in both the United States and the European Union in April 2021. [ 5 ] [ 6 ] [ 11 ] [ 8 ] [ 12 ] Based on the Garnet trial, dostarlimab gained accelerated approval from the US Food and Drug Administration (FDA) in April 2021, [ 6 ] and full approval in February 2023.

  4. Pituitary adenoma - Wikipedia

    en.wikipedia.org/wiki/Pituitary_adenoma

    Pituitary adenomas are tumors that occur in the pituitary gland. Most pituitary tumors are benign, approximately 35% are invasive and just 0.1% to 0.2% are carcinomas. [1] Pituitary adenomas represent from 10% to 25% of all intracranial neoplasms, with an estimated prevalence rate in the general population of approximately 17%. [1] [2]

  5. List of unproven and disproven cancer treatments - Wikipedia

    en.wikipedia.org/wiki/List_of_unproven_and...

    Shark cartilage – a dietary supplement made from ground shark skeleton, and promoted as a cancer treatment perhaps because of the mistaken notion that sharks do not get cancer. The Mayo Clinic conducted research and were "unable to demonstrate any suggestion of efficacy for this shark cartilage product in patients with advanced cancer". [177]

  6. US FDA staff raises concerns over data from J&J, Bristol's ...

    www.aol.com/news/us-fda-staff-flags-safety...

    The therapies - J&J's Carvykti and Bristol Myers' Abecma - are approved by the FDA to treat patients with multiple myeloma who have received at least four prior lines of treatment. The companies ...

  7. Osilodrostat - Wikipedia

    en.wikipedia.org/wiki/Osilodrostat

    The US Food and Drug Administration (FDA) approved osilodrostat based on the evidence from one clinical trial (NCT02180217) of 137 subjects with Cushing's disease. [6] The trial was conducted at 66 sites across 19 countries (United States, Argentina, Austria, Bulgaria, Canada, China, Columbia, Germany, Spain, France, Great Britain, India, Italy ...

  8. Enclomifene - Wikipedia

    en.wikipedia.org/wiki/Enclomifene

    Enclomifene (INN Tooltip International Nonproprietary Name), or enclomiphene (USAN Tooltip United States Adopted Name), a nonsteroidal selective estrogen receptor modulator of the triphenylethylene group, acts by antagonizing the estrogen receptor (ER) in the pituitary gland, which reduces negative feedback by estrogen on the hypothalamic-pituitary-gonadal axis, thereby increasing gonadotropin ...

  9. PD-1 and PD-L1 inhibitors - Wikipedia

    en.wikipedia.org/wiki/PD-1_and_PD-L1_inhibitors

    Avelumab is FDA approved for the treatment of metastatic merkel-cell carcinoma. It failed phase III clinical trials for gastric cancer. [33] Durvalumab (Imfinzi) is a fully human IgG1 antibody developed by AstraZeneca. Durvalumab is FDA approved for the treatment of urothelial carcinoma and unresectable non-small cell lung cancer after ...

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