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As primary teeth are being developed, the ingestion of fluoride causes the teeth to form stronger and more resistant to cavities, although this increases the risk of dental fluorosis. [ 10 ] [ 11 ] [ 12 ] Water and milk fluoridation are two forms of systemic fluoride therapy that are effective at preventing dental cavities.
Topical fluorides are fluoride-containing drugs indicated in prevention and treatment of dental caries, particularly in children's primary dentitions. [1] The dental-protecting property of topical fluoride can be attributed to multiple mechanisms of action, including the promotion of remineralization of decalcified enamel, the inhibition of the cariogenic microbial metabolism in dental plaque ...
Other symptoms include thickening of the bone structure and accumulation of bone tissue, which both contribute to impaired joint mobility. Ligaments and cartilage can become ossified. [3] Most patients with skeletal fluorosis show side effects from the high fluoride dose such as ruptures of the stomach lining and nausea. [4]
Fluoride varnish is widely used in the United Kingdom, following guidelines from multiple sources backing its efficacy. Public Health England, a UK government organisation sponsored by the Department of Health, released guidance in 2014 recommending fluoride varnish application at least twice yearly for children and young adults. [13]
Fluoride salts, particularly sodium fluoride (NaF), are used in the treatment and prevention of osteoporosis. [13] Symptoms such as fractured hips in the elderly or brittle and weak bones may be caused by fluorine deficiency in the body. [14] Fluoride stimulates bone formation and increases bone density; [15] however, bone with excess fluoride ...
Olaflur (INN, or amine fluoride 297) is a fluoride-containing substance that is an ingredient of toothpastes and solutions for the prevention of dental caries. [1] It has been in use since 1966. Especially in combination with dectaflur , it is also used in the form of gels for the treatment of early stages of caries, sensitive teeth , and by ...
[2] [3] [4] Ingestion of fluoride can produce gastrointestinal discomfort at doses at least 15 to 20 times lower (0.2–0.3 mg/kg or 10 to 15 mg for a 50 kg person) than lethal doses. [5] Although it is helpful topically for dental health in low dosage, chronic ingestion of fluoride in large amounts interferes with bone formation.
Also, although fluoride affects the physiology of dental bacteria, [90] its effect on bacterial growth does not seem to be relevant to cavity prevention. [91] Fluoride's effects depend on the total daily intake of fluoride from all sources. [51] About 70–90% of ingested fluoride is absorbed into the blood, where it distributes throughout the ...