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Epilepsy in animals is a group of neurological disorders characterized by seizures, caused by uncontrolled, abnormal bursts of electrical activity in the brain. They can start and stop very abruptly and last any amount of time from a few seconds to a few minutes. [ 1 ]
Animal models of epilepsy have helped to advance the understanding of how normal brains develop epilepsy (a process known as Epileptogenesis), and have been used in pre-clinical trials of antiepileptic drugs. [1] Epilepsy is a set of syndromes which have in common a predisposition to recurrent epileptic seizures. [2]
These initial observations led to the development of two breeding colonies: [3] [4] (i) a fully inbred strain of rats, with 100% of animals displaying the EEG and behavioral characteristics of absence seizures, derived from an outbred Wistar colony and called the Genetic Absence Epilepsy Rats from Strasbourg (GAERS) (ii) a strain of non epileptic control animals selected from the same initial ...
Kindling is a commonly used model for the development of seizures and epilepsy in which the duration and behavioral involvement of induced seizures increases after seizures are induced repeatedly. [1] Kindling is also referred as an animal visual model of epilepsy that can be produced by focal electrical stimulation in the brain.
Rage syndrome is also sometimes termed a form of epilepsy, particularly limbic epilepsy. [ 6 ] [ 7 ] The term limbic epilepsy for rage syndrome has been used synonymously with the terms psychomotor epilepsy, automatic epilepsy, rhinencephalic epilepsy, behavioral epilepsy, temporal lobe epilepsy, and autonomic epilepsy.
Racine stages are a categorization of rodent epileptic seizures proposed by Ronald J. Racine in 1972. Prior to Racine's research in animal epilepsy models, a quantifiable means to describe seizure intensities and their causes was not readily available.
Service dog for a boy with autism and seizures calms him during hospital stay. A seizure response dog (SRD) (also known as seizure dog) is a dog demonstrating specific assisting behaviour during or immediately after a person's epileptic seizure or other seizure. [1] [2] When reliably trained such dogs can serve as service dogs for people with ...
Epileptogenesis that occurs in human brains has been modeled in a variety of animal models and cell culture models. [2] Epileptogenesis is poorly understood, [6] and increasing understanding of the process may aid researchers in preventing seizures, diagnosing epilepsy, [23] and developing treatments to prevent it. [2]