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Graft-versus-host disease (GvHD) is a syndrome, characterized by inflammation in different organs. GvHD is commonly associated with bone marrow transplants and stem cell transplants. White blood cells of the donor's immune system which remain within the donated tissue (the graft) recognize the recipient (the host) as foreign (non-self).
TA-GvHD. Specialty. Hematology. Transfusion-associated graft-versus-host disease (TA-GvHD) is a rare complication of blood transfusion, in which the immunologically competent donor T lymphocytes mount an immune response against the recipient's lymphoid tissue. [1] These donor lymphocytes engraft, recognize recipient cells as foreign and mount ...
Hyperacute rejection is a form of rejection that manifests itself in the minutes to hours following transplantation. [4] It is caused by the presence of pre-existing antibodies in the recipient that recognize antigens in the donor organ. [5] These antigens are located on the endothelial lining of blood vessels within the transplanted organ and ...
Graft vs Host Disease (GvHD) occurs when the white blood cells produced by the donated (allogenic) stem cells (the graft) identify the patient’s cells/organs as "non-self," and attack them in a ...
Graft-versus-leukemia. Graft-versus-leukemia (GvL) is a specific type of GvT effect. As the name of this effect indicates, GvL is a reaction against leukemic cells of the host. GvL requires genetic disparity because the effect is dependent on the alloimmunity principle. GvL is a part of the reaction of the graft against the host.
Graft-versus-host disease (GvHD) is an inflammatory disease that is unique to allogeneic transplantation. It is an attack by the "new" bone marrow's immune cells against the recipient's tissues. This can occur even if the donor and recipient are HLA-identical because the immune system can still recognize other differences between their tissues.
However, besides the risk of graft failure, there is also a risk that the newly created white blood cells may attack the rest of the body ("graft-versus-host disease"). In young patients with an HLA-matched sibling donor, bone marrow transplant can be considered as a first-line treatment.
Theoretically, thymus transplantation could cause two types of graft-versus-host disease (GVHD): First, it could cause a donor T cell-related GVHD, because of T cells from the donor that are present in the transplanted thymus that recognizes the recipient as foreign. Donor T cells can be detected in the recipient after transplantation, but ...
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