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  2. Carcinoma in situ - Wikipedia

    en.wikipedia.org/wiki/Carcinoma_in_situ

    Carcinoma in situ (CIS) is a group of abnormal cells. [ 1 ] [ 2 ] While they are a form of neoplasm , [ 3 ] there is disagreement over whether CIS should be classified as cancer . This controversy also depends on the exact CIS in question (e.g., cervical, skin, breast).

  3. Cancer cell - Wikipedia

    en.wikipedia.org/wiki/Cancer_cell

    Cancer cells are cells that divide continually, forming solid tumors or flooding the blood or lymph with abnormal cells. Cell division is a normal process used by the body for growth and repair. A parent cell divides to form two daughter cells, and these daughter cells are used to build new tissue or to replace cells that have died because of ...

  4. In situ - Wikipedia

    en.wikipedia.org/wiki/In_situ

    In oncology, in situ is commonly applied in the context of carcinoma in situ (CIS), a term describing abnormal cells confined to their original location without invasion of surrounding tissue. [ 30 ] [ 31 ] CIS is a critical term in early cancer diagnosis , as it signifies a non-invasive stage, allowing for more targeted interventions before ...

  5. Cancer staging - Wikipedia

    en.wikipedia.org/wiki/Cancer_staging

    Stage 0: carcinoma in situ, abnormal cells growing in their normal place ("in situ" from Latin for "in its place"). Stage 0 can also mean no remaining cancer after preoperative treatment in some cancers (e.g. colorectal cancer). Stage I: cancers are localized to one part of the body. Stage I cancer can be surgically removed if small enough.

  6. Field cancerization - Wikipedia

    en.wikipedia.org/wiki/Field_cancerization

    Field cancerization or field effect (also termed field change, field change cancerization, field carcinogenesis, cancer field effect or premalignant field defect) is a biological process in which large areas of cells at a tissue surface or within an organ are affected by carcinogenic alterations. The process arises from exposure to an injurious ...

  7. TNM staging system - Wikipedia

    en.wikipedia.org/wiki/TNM_staging_system

    G (1–4): the grade of the cancer cells (i.e. they are "low grade" if they appear similar to normal cells, and "high grade" if they appear poorly differentiated) S (0–3): elevation of serum tumor markers; R (0–2): the completeness of the operation (resection-boundaries free of cancer cells or not) Pn (0–1): invasion into adjunct nerves

  8. Carcinogenesis - Wikipedia

    en.wikipedia.org/wiki/Carcinogenesis

    The cancer stem cell hypothesis proposes that the different kinds of cells in a heterogeneous tumor arise from a single cell, termed Cancer Stem Cell. Cancer stem cells may arise from transformation of adult stem cells or differentiated cells within a body. These cells persist as a subcomponent of the tumor and retain key stem cell properties.

  9. Tumor microenvironment - Wikipedia

    en.wikipedia.org/wiki/Tumor_microenvironment

    T cells must replicate after arriving at the tumor site to effectively kill the cancer cells, survive hostile elements and migrate through the stroma to the cancer cells. This is affected by the tumor microenvironment. The draining lymph nodes are the likely location for cancer specific T cell replication, although this also occurs within the ...