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In heart failure, the heart muscle weakens, and the ventricles stretch (dilate) to the point that the heart can't pump blood efficiently throughout the body. Blood clots: If clots enter the bloodstream, they can block blood flow to vital organs, possibly causing a heart attack or stroke.
The result is the formation of a thrombus (blood clot) overlying the atheroma, which obstructs blood flow acutely. With the obstruction of blood flow, downstream tissues are starved of oxygen and nutrients. If this is the myocardium (heart muscle) angina (cardiac chest pain) or myocardial infarction (heart attack) develops. [citation needed]
The aorta (/ eɪ ˈ ɔːr t ə / ay-OR-tə; pl.: aortas or aortae) is the main and largest artery in the human body, originating from the left ventricle of the heart, branching upwards immediately after, and extending down to the abdomen, where it splits at the aortic bifurcation into two smaller arteries (the common iliac arteries).
An atheroma, or atheromatous plaque, is an abnormal accumulation of material in the inner layer of an arterial wall. [ 1 ] [ 2 ] The material consists of mostly macrophage cells , [ 3 ] [ 4 ] or debris, containing lipids , calcium and a variable amount of fibrous connective tissue .
In CAD, atheromatous plaque formation in a coronary artery limits oxygen supply to cardiomyocytes, impairing heart contractility. CAD severity varies based on the extent of coronary artery occlusion. At 75% luminal narrowing, patients experience symptoms associated with limited perfusion of cardiomyocytes, [ 11 ] especially under strenuous ...
The hemodynamics of the aorta is an ongoing field of research in which the goal is to identify what flow patterns and subsequent forces occur within the thoracic aorta. These patterns and forces are used to identify the presence and severity of cardiovascular diseases such as aortic aneurysm and atherosclerosis . [ 1 ]
The researchers looked at several cardiovascular health outcomes among participants: stroke, heart attack, heart failure, aortic stenosis, atrial fibrillation, and abdominal aortic aneurysm.
Atherosclerosis is a hardening of an artery specifically due to an atheromatous plaque. The term atherogenic is used for substances or processes that cause atherosclerosis. Micrograph showing hyaline arteriolosclerosis in the kidney. PAS stain.