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Of solid tumor neoplasms, ovarian cancer is most likely to provoke eosinophilia, though any other cancer can cause the condition. [3] Solid epithelial cell tumors have been shown to cause both tissue and blood eosinophilia, with some reports indicating that this may be mediated by interleukin production by tumor cells, especially IL-5 or IL-3. [2]
When eosinophilic pneumonia is related to an illness such as cancer or parasitic infection, treatment of the underlying cause is effective in resolving the lung disease. When due to acute or chronic eosinophilic pneumonia, however, treatment with corticosteroids results in a rapid, dramatic resolution of symptoms over the course of one or two days.
More than 1,500/mL of blood eosinophilia for more than six months in a row, along with hypereosinophilic disease signs and symptoms. [23] Lack of an underlying cause for hypereosinophilia after a full diagnostic assessment. [23] Organ dysfunction or damage as a result of eosinophils' toxic contents being released locally. [23]
Another theory postulates that eosinophils in sepsis travel out of the blood and may contribute to tissue damage, causing relative eosinopenia in the blood with elevated eosinophils in affected tissue. [5] Eosinophils have been shown to have a cytotoxic effect on bacteria, which contributes to surrounding tissue damage. [2] [3]
Leukocytosis is a condition in which the white cell count is above the normal range in the blood. [1] [2] It is frequently a sign of an inflammatory response, [3] most commonly the result of infection, but may also occur following certain parasitic infections or bone tumors as well as leukemia.
[40] [9] Due to the prevalence of infection by H. pylori in middle-aged adults (74% in developing countries and 58% in developed countries in 2002 [41]), and 1% to 3% likelihood of infected individuals developing gastric cancer, [42] H. pylori-induced gastric cancer is the third highest cause of worldwide cancer mortality as of 2018.
Cardiovascular complications such as various types of heart damage due to eosinophilic myocarditis and vascular disorders due to eosinophil infiltration of the vascular wall that lead to vascular thrombosis are often critical components of persistent hypereosinophilia syndromes; [6] These complications are not a prominent component of ...
An eosinophil-based specific type of heart damage was first described by the Swiss doctor, Wilhelm Loeffler, in 1936. [ 3 ] [ 4 ] As initially described, the disorder manifests as a restrictive cardiomyopathy, i.e. a poorly expanding and contracting rigid heart that was infiltrated with eosinophils and showed replacement of heart cells by stiff ...