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Alternative pathway. (Some labels are in Polish.) The alternative pathway is a type of cascade reaction of the complement system and is a component of the innate immune system, a natural defense against infections. The alternative pathway is one of three complement pathways that opsonize and kill pathogens.
However, when C3b undergoes its post-cleavage conformational change, a binding site for a plasma protein called Factor B is also exposed. Factor B then binds to C3b and is cleaved by a plasma serine protease Factor D. The C3bBb complex (= alternative pathway C3 convertase) remains attached to the cell-surface.
Properdin (Factor P) is the only known positive regulator of complement activation that stabilizes the alternative C3 convertase (C3bBb). Properdin deficient individuals are sensitive to pyogenic infections. Properdin also promotes association of C3b with Factor B and thus it inhibits the Factor H mediated cleavage of C3b by Factor I. [6]
In the alternative pathway, C3b binds to Factor B. Factor D releases Factor Ba from Factor B bound to C3b. The complex of C3b(2)Bb is a protease which cleaves C5 into C5b and C5a. C5 convertase is also formed by the classical pathway when C3b binds C4b and C2b. C5a is an important chemotactic protein, helping recruit inflammatory cells.
Classical and alternative pathways shown with their corresponding proteins. The classical complement pathway is one of three pathways which activate the complement system, which is part of the immune system. The classical complement pathway is initiated by antigen-antibody complexes with the antibody isotypes IgG and IgM. [1] [2]
In mathematics and numerical analysis, an adaptive step size is used in some methods for the numerical solution of ordinary differential equations (including the special case of numerical integration) in order to control the errors of the method and to ensure stability properties such as A-stability. Using an adaptive stepsize is of particular ...
The step size is =. The same illustration for = The midpoint method converges faster than the Euler method, as .. Numerical methods for ordinary differential equations are methods used to find numerical approximations to the solutions of ordinary differential equations (ODEs).
"The Alternative Factor" is the twenty-seventh episode of the first season of the American science fiction television series Star Trek. Written by Don Ingalls and directed by Gerd Oswald, it first aired on March 30, 1967. In the episode, the crew of the USS Enterprise encounters a "reality jumping" madman.