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The medial forebrain bundle may serve as a target in treating treatment-resistant depression. [8] Since the MFB connects areas of the brain which are involved with motivated behavior, mood regulation, and antidepressant response the stimulation of the MFB through deep brain stimulation could be an effective form of treatment.
The medial forebrain bundle (MFB) is the location of the most frequently investigated brain stimulation reward sites, and it is composed of a complex bundle of axons projecting from the basal olfactory regions and the septal nuclei. [3]
It is one of the component pathways of the medial forebrain bundle, which is a set of neural pathways that mediate brain stimulation reward. [10] The VTA is located in the midbrain and consists of dopaminergic, GABAergic, and glutamatergic neurons. [11]
Medial forebrain bundle; Medial longitudinal fasciculus; Myoclonic triangle; Solitary tract; Major dopaminergic pathways from dopaminergic cell groups. Mesocortical pathway; Mesolimbic pathway; Nigrostriatal pathway; Tuberoinfundibular pathway; Serotonergic pathways. Raphe Nuclei; Norepinephrine Pathways Locus coeruleus and other noradrenergic ...
The medial forebrain bundle, which is a set of many neural pathways that mediate brain stimulation reward (i.e., reward derived from direct electrochemical stimulation of the lateral hypothalamus), is also a component of the reward system. [24]
Other axons arising from these cells descend through the medial forebrain bundle to terminate in a region dorsal to the interpeduncular nucleus. The lateral septum is a relay center for connections from the CA3 of the hippocampus to the ventral tegmental area.
The axons from dopamine neurons emanate from a primary dendrite and project ipsilaterally (on the same side) via the medial forebrain bundle to the dorsal striatum. There is a rough topographical correlation between the anatomical localization of the dopamine cell body within the SNc and the area of termination in the dorsal striatum.
A small ascending dorsal serotonergic pathway arising from the ventral and dorsal superior raphe nuclei initially travels in the DLF, with some of its fibres terminating in the periaqueductal gray of the midbrain, and the posterior hypothalamus; the majority of its fibers however pass beyond the DLF in the medial forebrain bundle, here uniting ...