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The medial forebrain bundle may serve as a target in treating treatment-resistant depression. [8] Since the MFB connects areas of the brain which are involved with motivated behavior, mood regulation, and antidepressant response the stimulation of the MFB through deep brain stimulation could be an effective form of treatment.
It is one of the component pathways of the medial forebrain bundle, which is a set of neural pathways that mediate brain stimulation reward. [10] The VTA is located in the midbrain and consists of dopaminergic, GABAergic, and glutamatergic neurons. [11]
The lateral hypothalamus is a portion of the hypothalamus, and brain stimulation to this area at the level of the medial forebrain bundle produces the highest response rates and subsequently the highest reward potency in rodents. Lesions in this region or along its boundary cause a loss of positive drive-reward behaviors as well as all other ...
A small ascending dorsal serotonergic pathway arising from the ventral and dorsal superior raphe nuclei initially travels in the DLF, with some of its fibres terminating in the periaqueductal gray of the midbrain, and the posterior hypothalamus; the majority of its fibers however pass beyond the DLF in the medial forebrain bundle, here uniting ...
The axons from dopamine neurons emanate from a primary dendrite and project ipsilaterally (on the same side) via the medial forebrain bundle to the dorsal striatum. There is a rough topographical correlation between the anatomical localization of the dopamine cell body within the SNc and the area of termination in the dorsal striatum.
The limbic system, also known as the paleomammalian cortex, is a set of brain structures located on both sides of the thalamus, immediately beneath the medial temporal lobe of the cerebrum primarily in the forebrain. [1] Its various components support a variety of functions including emotion, behavior, long-term memory, and olfaction. [2]
The hypothalamotegmental tract is a pathway from the hypothalamus to the reticular formation. [1] Axons from the posterior hypothalamus descend through the midbrain and pontine reticular formation.
Medial parabrachial nucleus; Lateral parabrachial nucleus; Subparabrachial nucleus (Kölliker-Fuse nucleus) Pontine respiratory group; Superior olivary complex. Medial superior olive; Lateral superior olive; Medial nucleus of the trapezoid body; Paramedian pontine reticular formation; Parvocellular reticular nucleus; Caudal pontine reticular ...