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Blood urea nitrogen (BUN) is a medical test that measures the amount of urea nitrogen found in blood. The liver produces urea in the urea cycle as a waste product of the digestion of protein . Normal human adult blood should contain 7 to 18 mg/dL (0.388 to 1 mmol/L) of urea nitrogen. [ 1 ]
Urea nitrogen is the end product of breakdown of proteins in the body. In individuals with normal kidney and liver functions, urea is excreted via urine.
The blood urea nitrogen (BUN) test is a measure of the amount of nitrogen in the blood that comes from urea. It is used as a marker of renal function , though it is inferior to other markers such as creatinine because blood urea levels are influenced by other factors such as diet, dehydration, [ 35 ] and liver function.
Measurements of urea and creatinine (Cr) in the blood are used to assess renal function. For historical reasons, the lab test measuring urea is known as "blood urea nitrogen" (BUN) in the US. The BUN:Cr ratio is a useful measure in determining the type of azotemia and will be discussed in each section below. A normal BUN:Cr is equal to 15. [3]
It is an ammonia odour in the mouth caused by the high concentration of urea in the saliva, which subsequently breaks down to ammonia. [12] As the blood urea nitrogen (BUN) level increases, patients might develop uremic stomatitis. Uremic stomatitis appears as a pseudo membrane or frank ulcerations with redness and a pultaceous coat in the mouth.
In medicine, the urea-to-creatinine ratio (UCR [1]), known in the United States as BUN-to-creatinine ratio, is the ratio of the blood levels of urea (mmol/L) and creatinine (Cr) (μmol/L). BUN only reflects the nitrogen content of urea (MW 28) and urea measurement reflects the whole of the molecule (MW 60), urea is just over twice BUN (60/28 ...
The urea cycle and the citric acid cycle are independent cycles but are linked. One of the nitrogen atoms in the urea cycle is obtained from the transamination of oxaloacetate to aspartate. [11] The fumarate that is produced in step three is also an intermediate in the citric acid cycle and is returned to that cycle. [11]
Urine contains water-soluble by-products of cellular metabolism that are rich in nitrogen and must be cleared from the bloodstream, such as urea, uric acid, and creatinine. A urinalysis can detect nitrogenous wastes of the mammalian body. Urine plays an important role in the earth's nitrogen cycle.