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Silicone gel sheeting produces a statistically significant reduction in scar thickness and color amelioration. Therefore, it is an evidence-based non-invasive preventive treatment. [24] Results of comparative studies on the effectiveness of silicone gel sheeting and silicone gel do not show significant differences between the two. [25]
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Mederma is a topical product used to improve scar appearance. It is a gel based on an onion extract. Mederma is product of HRA Pharma, a division of Perrigo. A Mederma marketing claim is that the product can can make scars "softer, smoother, and less noticeable". [1]
Silicone gel sheets may improve the appearance of scars slightly compared with applying onion extract, and may reduce pain compared with no treatment with silicone gel sheets or pressure garments. [8] It is uncertain whether silicone gel sheets are more effective than other treatment approaches. [8]
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Silicone scar treatments are commonly used in preventing scar formation and improving existing scar appearance. [50] A meta-study by the Cochrane collaboration found weak evidence that silicone gel sheeting helps prevent scarring. [51] However, the studies examining it were of poor quality and susceptible to bias. [51]