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Systemic mastocytosis involves the bone marrow in the majority of cases and in some cases other internal organs, usually in addition to involving the skin. Mast cells collect in various tissues and can affect organs where mast cells do not normally inhabit such as the liver , spleen and lymph nodes , and organs which have normal populations but ...
Clinical features of a bone tumor depend on the type of tumor and which part of which bone is affected. [2] [13] Symptoms and signs usually result from the pressure effect of the tumor. [1] There may be a lump, with or without pain. [1] Pain may increase with the growth of the tumor and may be worse at night and at rest. [1] [3] A bone tumor ...
The more aggressive forms of disease require treatment with chemotherapy, radiotherapy, immunotherapy and—in some cases—a bone marrow transplant. The use of rituximab has been established for the treatment of B-cell–derived hematologic malignancies, including follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL). [7]
Bone marrow samples can be obtained by aspiration and trephine biopsy. Sometimes, a bone marrow examination will include both an aspirate and a biopsy. The aspirate yields semi-liquid bone marrow, which can be examined by a pathologist under a light microscope and analyzed by flow cytometry, chromosome analysis, or polymerase chain reaction (PCR
The main symptoms include persistent bone pain that gets worse, swelling and redness over a bone, a noticeable lump over a bone, a bone that breaks or fractures more easily than normal, and ...
Stage III - multiple skin tumors or a large tumor invading deep to the skin with or without lymph node involvement; Stage IV – a tumor with metastasis to the spleen, liver, or bone marrow, or with the presence of mast cells in the blood [10] X-rays, ultrasound, or lymph node, bone marrow, or organ biopsies may be necessary to stage the disease.
Bone pain, joint pain (caused by the spread of "blast" cells to the surface of the bone or into the joint from the marrow cavity) Breathlessness; Enlarged lymph nodes, liver, and/or spleen; Pitting edema (swelling) in the lower limbs and/or abdomen; Petechiae, which are tiny red spots or lines in the skin due to low platelet levels; Testicular ...
Chronic lymphocytic leukemia (CLL) is a type of cancer that affects the blood and bone marrow. [8] [9] In CLL, the bone marrow makes too many lymphocytes, which are a type of white blood cell. [8] [9] In patients with CLL, B cell lymphocytes can begin to collect in their blood, spleen, lymph nodes, and bone marrow.