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A dose–response curve is a coordinate graph relating the magnitude of a dose (stimulus) to the response of a biological system. A number of effects (or endpoints) can be studied. The applied dose is generally plotted on the X axis and the response is plotted on the Y axis. In some cases, it is the logarithm of the dose that is plotted on the ...
Rats are shown to self-administer amfonelic acid in a dose-dependent manner. [12] Though AFA was discovered in the course of antibiotic research, there is very little data available on the drug's antimicrobial activity.
A quantal dose response curve shows the percentage of subjects where a response is noted in an all-or-none manner (y axis) over the dose of the drug (x axis). For competition binding assays and functional antagonist assays IC 50 is the most common summary measure of the dose-response curve
Type A: augmented pharmacological effects, which are dose-dependent and predictable [5]; Type A reactions, which constitute approximately 80% of adverse drug reactions, are usually a consequence of the drug's primary pharmacological effect (e.g., bleeding when using the anticoagulant warfarin) or a low therapeutic index of the drug (e.g., nausea from digoxin), and they are therefore predictable.
Ultrasensitivity was observed both in a dose-dependent manner (nH=5±0.2), by treating cells with different HU-210 concentrations for a fixed time, and in a duration-dependent manner (nH=8.6±0.8), by treating cells with a fixed HU-210 concentration during varying times. [citation needed]
Cerivastatin also induced myopathy in a dose-dependent manner when administered as monotherapy, but that was revealed only after Bayer was sued and unpublished company documents were opened. [ 5 ] Structure and reactivity
Interestingly, notwithstanding the pain response induced by the toxin, Makatoxin-3 also shows an analgesic effect in a dose-dependent manner (50 nmol/kg, 150 nmol/kg, and 450 nmol/kg). 450 nmol/kg elicits an 80% reduction of paw-flinch pain behavior in mice when they are intraperitoneally injected with another pain-inducing substance 30 minutes ...
All pathogens have an infectious dose typically given in number of cells. The infectious dose varies by organism and can be dependent on the specific type of strain. [21] Some pathogens can infect a host with only a few cells, while others require millions or billions. Examples of infectious doses, ranked loosely in increasing order: [22]